PROTAC Linker 15

Names

[ Name ]:
PROTAC Linker 15

[Synonym ]:
t-Boc-N-Amido-PEG3-Amine
13-AMINO-5,8,11-TRIOXA-2-AZATRIDECANOIC ACID 1,1-DIMETHYLETHYL ESTER
1-Boc-amine-11-amino-3,6,9-trioxaundecane

Biological Activity

[Description]:

PROTAC Linker 15 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 15 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.05

[ Molecular Formula ]:
C₁₃H₂₈N₂O₅

[ Molecular Weight ]:
292.37200

[ Exact Mass ]:
292.20000

[ PSA ]:
92.04000

[ LogP ]:
1.61080

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%