Methanesulfonyl chloride
Controlled Substances
Names
[ CAS No. ]:
124-63-0
[ Name ]:
Methanesulfonyl chloride
[Synonym ]:
Intermediates: Methanesulfonyl Chloride
Methanesulfonyl chloride
methane sulfonyl chloride
methanesulfonoyl chloride
METHANESULFONYLCHLORIDE
Methylsulfonyl chloride
METHANESULFONYL CHLORIDE FOR PHARMA SYNTHESIS
Methanesulphonyl chloride
EINECS 204-706-1
chloromethylsulfone
Methanesulfonic acid chloride
METHANESULFONYL CHLORIDE (100 ML )
Methanesulfuryl chloride
METHANE SULFONYL CHLORIDE,[124-63-0]
METHANE SULFONYL CHLORIDE(MSC)
Methyl sulfonyl chloride
Chloromethyl sulfone
Mesyl chloride
Methyl sulfochloride
MFCD00007454
Methane sulphonyl chloride
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Boiling Point ]:
160.7±0.0 °C at 760 mmHg
[ Melting Point ]:
-33°C
[ Molecular Formula ]:
CH3ClO2S
[ Molecular Weight ]:
114.551
[ Flash Point ]:
42.2±18.7 °C
[ Exact Mass ]:
113.954224
[ PSA ]:
42.52000
[ LogP ]:
0.23
[ Vapour Pressure ]:
3.1±0.2 mmHg at 25°C
[ Index of Refraction ]:
1.438
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- PB2790000
- CHEMICAL NAME :
- Methanesulfonyl chloride
- CAS REGISTRY NUMBER :
- 124-63-0
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 14
- MOLECULAR FORMULA :
- C-H3-Cl-O2-S
- MOLECULAR WEIGHT :
- 114.55
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - hematuria
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 620 mg/m3/6H
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands Skin and Appendages - hair
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - hematuria
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - hematuria
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 100 uL/kg
- TOXIC EFFECTS :
- Skin and Appendages - dermatitis, other (after systemic exposure)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg/2W-I
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Gastrointestinal - changes in structure or function of esophagus Nutritional and Gross Metabolic - weight loss or decreased weight gain
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 32 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 390,105,1997 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5012 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 851 (estimated) No. of Female Employees: 187 (estimated)
Safety Information
[ Symbol ]:
GHS05, GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H300 + H310 + H330-H314-H335
[ Precautionary Statements ]:
P260-P264-P280-P284-P301 + P310-P302 + P350
[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
C:Corrosive
[ Risk Phrases ]:
R22;R35
[ Safety Phrases ]:
S26-S28-S36/37/39-S45-S25-S28A
[ RIDADR ]:
UN 3246 6.1/PG 1
[ WGK Germany ]:
2
[ RTECS ]:
PB2790000
[ Packaging Group ]:
I
[ Hazard Class ]:
6.1
[ HS Code ]:
2904100000
Customs
[ HS Code ]: 2904909090
[ Summary ]:
HS:2904909090 sulphonated, nitrated or nitrosated derivatives of hydrocarbons, whether or not halogenated VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%