Azido-PEG4-alcohol

Names

[ Name ]:
Azido-PEG4-alcohol

[Synonym ]:
1-AZIDO-3,6,9-TRIOXAUNDECANE-11-OL
Azido-PEG4-alcohol
1-azido-3,6,9-trioxaundecan-11-ol
1-azido-11-hydroxy-3,6,9-trioxaundecane

Biological Activity

[Description]:

Azido-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈H₁₇N₃O₄

[ Molecular Weight ]:
219.23800

[ Exact Mass ]:
219.12200

[ PSA ]:
97.67000

[ Index of Refraction ]:
1.47

MSDS

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Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds

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