Azide-PEG4-Tos

Names

[ Name ]:
Azide-PEG4-Tos

[Synonym ]:
11-azido-3,6,9-trioxa-undecanyl p-toluenesulfonate
2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulfonate
toluene-4-sulfonic acid 2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethyl ester
2-[2-[2-(2-AZIDOETHOXY)ETHOXY]ETHOXY]-1-(P-TOLUENESULFONYL)-ETHANOL
2-{2-[2-(2-azido-ethoxy)-ethoxy]-ethoxy}-ethyl tosylate

Biological Activity

[Description]:

Azide-PEG4-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₂₃N₃O₆S

[ Molecular Weight ]:
373.42500

[ Exact Mass ]:
373.13100

[ PSA ]:
140.19000

[ LogP ]:
1.98076

[ Storage condition ]:
2-8°C

Azide-PEG4-Tos

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds