168640-82-2

168640-82-2 structure

Name: Azide-PEG4-Tos
Chemical Name: 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-1-(2-methylphenyl)sulfonylethanol
CAS Number: 168640-82-2
Molecular Formula: C₁₅H₂₃N₃O₆S
Molecular Weight: 373.42500
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2016-12-24 20:41:21
Modify Date: 2024-01-10 09:59:04
Azide-PEG4-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-1-(2-methylphenyl)sulfonylethanol
Synonyms	11-azido-3,6,9-trioxa-undecanyl p-toluenesulfonate 2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulfonate toluene-4-sulfonic acid 2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethyl ester 2-[2-[2-(2-AZIDOETHOXY)ETHOXY]ETHOXY]-1-(P-TOLUENESULFONYL)-ETHANOL 2-{2-[2-(2-azido-ethoxy)-ethoxy]-ethoxy}-ethyl tosylate

Description	Azide-PEG4-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula	C₁₅H₂₃N₃O₆S
Molecular Weight	373.42500
Exact Mass	373.13100
PSA	140.19000
LogP	1.98076
Storage condition	2-8°C

86770-67-4

98-59-9

~93%

168640-82-2

Literature: Yue, Xuyi; Feng, Yue; Yu, Y. Bruce Journal of Fluorine Chemistry, 2013 , vol. 152, p. 173 - 181

37860-51-8

~78%

168640-82-2

Literature: Dao, Kinh-Luan; Sawant, Rupa R.; Hendricks, J. Adam; Ronga, Victoria; Torchilin, Vladimir P.; Hanson, Robert N. Bioconjugate Chemistry, 2012 , vol. 23, # 4 p. 785 - 795

112-60-7

168640-82-2

Literature: Meunier, Serge J.; Wu, Quigquan; Wang, Sho-Nong; Roy, Rene Canadian Journal of Chemistry, 1997 , vol. 75, # 11 p. 1472 - 1482

98-59-9

168640-82-2

Literature: Gobbo, Pierangelo; Novoa, Samantha; Biesinger, Mark C.; Workentin, Mark S. Chemical Communications, 2013 , vol. 49, # 38 p. 3982 - 3984

77544-60-6

168640-82-2

Literature: Yue, Xuyi; Feng, Yue; Yu, Y. Bruce Journal of Fluorine Chemistry, 2013 , vol. 152, p. 173 - 181

Precursor 5
86770-67-4 98-59-9 37860-51-8 112-60-7
77544-60-6
DownStream 1
31521-83-2

168640-82-2	236754-49-7
62921-76-0	875770-32-4
1807539-01-0	1872433-61-8
2107273-40-3	2107273-38-9
1817735-42-4	2107273-56-1