N-Boc-PEG4-alcohol

Names

[ Name ]:
N-Boc-PEG4-alcohol

[Synonym ]:
tert-butyl N-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]carbamate
N-Boc-PEG4-alcohol

Biological Activity

[Description]:

PROTAC Linker 12 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 12 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.078g/cm3

[ Boiling Point ]:
414ºC at 760mmHg

[ Molecular Formula ]:
C₁₃H₂₇NO₆

[ Molecular Weight ]:
293.35700

[ Flash Point ]:
204.2ºC

[ Exact Mass ]:
293.18400

[ PSA ]:
86.25000

[ LogP ]:
0.94410

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.459

Safety Information

[ Hazard Codes ]:
Xn

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%