E3 ligase Ligand-Linker Conjugates 8
Modify Date: 2025-08-22 19:10:11
E3 ligase Ligand-Linker Conjugates 8 structure
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Common Name | E3 ligase Ligand-Linker Conjugates 8 | ||
|---|---|---|---|---|
| CAS Number | 1835705-55-9 | Molecular Weight | 751.42 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C38H59ClN4O7S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of E3 ligase Ligand-Linker Conjugates 8E3 ligase Ligand-Linker Conjugates 8 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology. |
| Name | E3 ligase Ligand-Linker Conjugates 8 |
|---|
| Description | E3 ligase Ligand-Linker Conjugates 8 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology. |
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| Related Catalog | |
| Target |
E3 Ligase Ligand-Linker Conjugate[1] |
| In Vitro | E3 ligase Ligand-Linker Conjugates 8 uses the cereblon ligand[1]. The linker is 6-2-2-6. The linkers contain a mixture of hydrophobic and hydrophilic moieties to balance the hydrophobicity/hydrophilicity of the resulting hybrid compounds. PROTACs that induce the degradation of an oncogenic tyrosine kinase, BCR-ABL has been developed. E3 ligase Ligand-Linker Conjugates 8 can be attached to potent TKIs (bosutinib and dasatinib) that mediate the degradation of c-ABL and BCR-ABL by hijacking either CRBN or VHL E3 ubiquitin ligase [2]. |
| References |
[1]. US 20170121321 A1 |
| Molecular Formula | C38H59ClN4O7S |
|---|---|
| Molecular Weight | 751.42 |