E3 ligase Ligand-Linker Conjugates 10

Modify Date: 2024-01-16 08:58:37

E3 ligase Ligand-Linker Conjugates 10 structure	Common Name	E3 ligase Ligand-Linker Conjugates 10
	CAS Number	1835705-57-1	Molecular Weight	651.26
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₂H₄₇ClN₄O₆S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of E3 ligase Ligand-Linker Conjugates 10

E3 ligase Ligand-Linker Conjugates 10 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.

Name	E3 ligase Ligand-Linker Conjugates 10

Description	E3 ligase Ligand-Linker Conjugates 10 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.
Related Catalog	Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate Research Areas >> Cancer
Target	E3 Ligase Ligand-Linker Conjugate[1]
In Vitro	E3 ligase Ligand-Linker Conjugates 10 uses the VHL ligand[1]. The linker is 6-2-2. The linkers contain a mixture of hydrophobic and hydrophilic moieties to balance the hydrophobicity/hydrophilicity of the resulting hybrid compounds. PROTACs that induce the degradation of an oncogenic tyrosine kinase, BCR-ABL has been developed. E3 ligase Ligand-Linker Conjugates 10 can be attached to potent TKIs (bosutinib and dasatinib) that mediate the degradation of c-ABL and BCR-ABL by hijacking either CRBN or VHL E3 ubiquitin ligase [2].
References	[1]. US 20170121321 A1 [2]. Lai AC, et al. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10.

Molecular Formula	C₃₂H₄₇ClN₄O₆S
Molecular Weight	651.26