692739-25-6

692739-25-6 structure

Name: 6-Maleimidocaproic acid-PFP ester
Chemical Name: pentafluorophenyl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate
CAS Number: 692739-25-6
Molecular Formula: C₁₆H₁₂F₅NO₄
Molecular Weight: 377.26300
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-27 03:49:06
Modify Date: 2024-01-03 11:45:18
6-Maleimidocaproic acid-PFP ester is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	pentafluorophenyl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate
Synonyms	6-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-hexanoic acid pentafluorophenyl ester 6-maleimidohexanoic acid pentafluorophenyl ester pentafluorophenyl 6-maleimidohexanoate

Description	6-Maleimidocaproic acid-PFP ester is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl-Chain
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562