Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.


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LY393615

LY393615 (NCC1048) is a novel neuronal Ca2+ (calcium channel) and Na + channel (sodium channel) blocker with IC50s of 1.9 μΜ and 5.2 μΜ for α1A and α1B calcium channel subunits. LY393615 has good brain penetration and neuroprotective effects in models of in cerebral ischemia that can be used for neurological disease research[1].

  • CAS Number: 325819-97-4
  • MF: C21H26ClF2NO
  • MW: 381.89
  • Catalog: Calcium Channel
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Gabapentin HCl

Gabapentin (Neurontin) is a pharmaceutical drug, specifically a GABA analog. It was originally developed to treat epilepsy, and currently is also used to relieve neuropathic pain.IC50 Value: 140 nM (α2δ subunit of calcium channel) [1]Target: Calcium Channelin vitro: Gabapentin, baclofen and CGP 44532 all reduced the electrically stimulated release of [3H]glutamic acid (IC50=20 microM, 0.8 microM and 2 microM, respectively). Gabapentin was without effect on the release of [3H]GABA, whilst baclofen (IC50=8 microM) and CGP 44532 (IC50=1 microM) inhibited [3H]GABA release [2]. A large inhibition of calcium currents by gabapentin was observed in pyramidal neocortical cells (up to 34%). Significantly, the gabapentin-mediated inhibition of calcium currents saturated at particularly low concentrations (around 10 microM), at least in neocortical neurons (IC50 about 4 microM) [3].in vivo: Gabapentin produced an anti-allodynic effect over the 7-day period, reducing the expression of pro-inflammatory cytokines but increasing the expression of IL-10 (TNF-α, 316.0 ± 69.7 pg/mL vs 88.8 ± 24.4 pg/mL; IL-1β, 1,212.9 ± 104.5 vs 577.4 ± 97.1 pg/mL; IL-6, 254.0 ± 64.8 pg/mL vs 125.5 ± 44.1 pg/mL; IL-10, 532.1 ± 78.7 pg/mL vs 918.9 ± 63.1 pg/mL). The suppressive effect of gabapentin on pro-inflammatory cytokine expression was partially blocked by the anti-IL-10 antibody [4].Toxicity: No new safety signals or adverse event trends relating to GEn exposure were identified [5].Clinical trial: N/A

  • CAS Number: 60142-95-2
  • MF: C9H18ClNO2
  • MW: 207.69800
  • Catalog: Calcium Channel
  • Density: N/A
  • Boiling Point: 314.4ºC at 760mmHg
  • Melting Point: 148-151℃ (ethanol )
  • Flash Point: 144ºC

L-Phenylalanine-13C9

L-Phenylalanine-13C9 ((S)-2-Amino-3-phenylpropionic acid-13C9) is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

  • CAS Number: 439685-11-7
  • MF: 13C9H11NO2
  • MW: 174.12
  • Catalog: Calcium Channel
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Leconotide

ω-Conotoxin CVID (Leconotide, AM336, CNSB004) blocks neuronal voltage sensitive calcium channel[1].

  • CAS Number: 247207-64-3
  • MF: C107H179N35O36S7
  • MW: 2756.26
  • Catalog: Calcium Channel
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Yangambin

Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca2+ influx through voltage-gated Ca2+ channels, leading to the reduction in [Ca2+]i in vascular smooth muscle cells and consequent peripheral vasodilation[1]. Yangambin exhibits the antiallergic activity against β-hexosaminidase release with an IC50 of 33.8 μM and for anti-inflammatory activity with an IC50 of 37.4 μM[2].

  • CAS Number: 13060-14-5
  • MF: C24H30O8
  • MW: 446.49000
  • Catalog: Calcium Channel
  • Density: 1.183g/cm3
  • Boiling Point: 556.1ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 221.1ºC

SOR-C13

SOR-C13, a carboxy-terminal truncated peptide, is a high-affinity TRPV6 antagonist with an IC50 value of 14 nM. TRPV6 is a non-voltage gated calcium channel that is associated with malignancy and poor prognosis in breast cancer. SOR-C13 has anticancer activity[1].

  • CAS Number: 1187852-48-7
  • MF: C72H116N20O19
  • MW: 1565.81
  • Catalog: Calcium Channel
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

diltiazem hydrochloride

Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist).

  • CAS Number: 33286-22-5
  • MF: C22H27ClN2O4S
  • MW: 450.979
  • Catalog: Calcium Channel
  • Density: 1.26g/cm3
  • Boiling Point: 594.4ºC at 760mmHg
  • Melting Point: 212-214 °C
  • Flash Point: 313.3ºC

β-Cyfluthrin

β-Cyfluthrin (beta-Cyfluthrin) is a type II synthetic pyrethroid and also an active ingredient of many insecticide products used for pestsin agriculture. β-Cyfluthrin is a neurotoxicant and affects calcium concentration in nervous tissue by inhibiting Ca2+ ATPase involved in calcium transport[1].

  • CAS Number: 1820573-27-0
  • MF: C22H18Cl2FNO3
  • MW: 434.29
  • Catalog: Calcium Channel
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Efonidipine (hydrochloride)

Efonidipine Hcl (NZ-105) is a dual T-type and L-type calcium channel blocker (CCB).IC50 value: Target: calcium channel blockerin vitro: Efonidipine and nifedipine, but not other examined CCBs, also increased the N(6), 2'-O-dibutyryladenosine 3',5'-cyclic monophosphate (dbcAMP)-induced StAR mRNA, which reflects the action of adrenocorticotropic hormone, and efonidipine and R(-)-efonidipine enhanced the dbcAMP-induced DHEA-S production in NCI-H295R adrenocortical carcinoma cells [1]. I(Ca(T)) was blocked mainly by a tonic manner by nifedipine, by a use-dependent manner by mibefradil, and by a combination of both manners by efonidipine. IC50s of these Ca2+ channel antagonists to I(Ca(T)) and L-type Ca2+ channel current (I(Ca(L))) were 1.2 micromol/l and 0.14 nmol/l for nifedipine; 0.87 and 1.4 micromol/l for mibefradil, and 0.35 micromol/l and 1.8 nmol/l for efonidipine, respectively [4].in vivo: Twenty hypertensive patients on chronic hemodialysis were given efonidipine 20-60 mg twice daily and amlodipine 2.5-7.5 mg once daily for 12 weeks each in a random crossover manner. The average blood pressure was comparable between the efonidipine and amlodipine periods (151 + or - 15/77 + or - 8 versus 153 + or - 15/76 + or - 8 mmHg). The pulse rate did not change significantly during the administration periods [2]. In the UM-X7.1 group, EFO treatment significantly attenuated the decrease of LVEF without affecting blood pressure compared with the vehicle group. EFO treatment decreased heart rate (by approximately 10%) in both groups [3].

  • CAS Number: 111011-53-1
  • MF: C34H39ClN3O7P
  • MW: 668.11600
  • Catalog: Calcium Channel
  • Density: N/A
  • Boiling Point: 746.9ºC at 760 mmHg
  • Melting Point: 169-170ºC
  • Flash Point: 405.5ºC

Ned-K

Ned-K is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Ned-K is effective at dampening simulated ischaemia and reperfusion (sIR)-induced Ca2+ oscillations in cardiomyocytes[1].

  • CAS Number: 2250019-90-8
  • MF: C31H31N5O3
  • MW: 521.61
  • Catalog: Calcium Channel
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

(Rac)-MEM 1003

(Rac)-MEM 1003 is the racemate of MEM 1003. MEM 1003, a dihydropyridine compound, is a potent L-type Ca2+ channel antagonist and has the potential for Alzheimer’s disease research[1].

  • CAS Number: 165187-25-7
  • MF: C22H25ClN2O5
  • MW: 432.90
  • Catalog: Calcium Channel
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

1,1'-Diheptyl-4,4'-bipyridinium dibromide

DHBP dibromide is an inhibitor for calcium release and a muscle relaxant.

  • CAS Number: 6159-05-3
  • MF: C24H38Br2N2
  • MW: 514.380
  • Catalog: Calcium Channel
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: 285 °C (dec.)(lit.)
  • Flash Point: N/A

Praeruptorin E

Praeruptorin E is a main bioactive constituent of Peucedanum praeruptorum (also known as Bai-Hua Qian Hu). Praeruptorin C is a calcium antagonist with pD2′ value of 5.2[1].

  • CAS Number: 78478-28-1
  • MF: C24H28O7
  • MW: 428.475
  • Catalog: Calcium Channel
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 516.5±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 221.4±30.2 °C

Calcium Channel antagonist 3

Calcium Channel antagonist 3 (compound 397) is an inhibitor of voltage-gated calcium channels with an IC50 value of 5-20μM[1].

  • CAS Number: 687573-14-4
  • MF: C23H26N2O4S
  • MW: 426.53
  • Catalog: Calcium Channel
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Isradipine-d6

Isradipine-d6 is the deuterium labeled Isradipine[1]. Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease[2][3][4].

  • CAS Number: 1261398-97-3
  • MF: C19H15D6N3O5
  • MW: 377.42
  • Catalog: Autophagy
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

1,2,4-Trihydroxybenzene

1,2,4-Trihydroxybenzene (Hydroxyhydroquinone), a by-product of coffee bean roasting, increases intracellular Ca2+ concentration in rat thymic lymphocytes[1].

  • CAS Number: 533-73-3
  • MF: C6H6O3
  • MW: 126.110
  • Catalog: Calcium Channel
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 334.5±12.0 °C at 760 mmHg
  • Melting Point: 140 °C (subl.)(lit.)
  • Flash Point: 176.9±14.2 °C

Zonisamide-d4

Zonisamide-d4 (AD 810-d4) is the deuterium labeled Zonisamide. Zonisamide (AD 810) is an inhibitor of zinc enzyme carbonic anhydrase (CA), with Kis of 35.2 nM and 20.6 nM for human mitochondrial isozyme hCA II and hCA V, respectively. Zonisamide has antiepileptic activity. Zonisamide can be used for the rsearch for epilepsy, seizures and Parkinson's disease[1][2].

  • CAS Number: 1020720-04-0
  • MF: C8H4D4N2O3S
  • MW: 216.25000
  • Catalog: Calcium Channel
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Ethacrynic acid sodium

Ethacrynic acid (Etacrynic acid sodium) sodium is a diuretic. Ethacrynic acid sodium is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid sodium is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid sodium also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid sodium has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice[1][2][3][4].

  • CAS Number: 6500-81-8
  • MF: C13H11Cl2NaO4
  • MW: 325.12
  • Catalog: Calcium Channel
  • Density: N/A
  • Boiling Point: 480ºC at 760 mmHg
  • Melting Point: 121-122ºC
  • Flash Point: 244.1ºC

McN5691

McN5691 is a voltage-sensitive calcium channel blocker.

  • CAS Number: 99254-95-2
  • MF: C30H35NO3
  • MW: 457.604
  • Catalog: Calcium Channel
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 595.6±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 156.4±27.3 °C

AE0047 Hydrochloride

AE0047 Hydrochloride is a calcium blocker, used in the research of hypertensive disease.

  • CAS Number: 116308-56-6
  • MF: C41H43ClN4O6
  • MW: 723.25600
  • Catalog: Calcium Channel
  • Density: N/A
  • Boiling Point: 799.4ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 437.3ºC

(±)-Felodipine-d5

Felodipine-d5 is deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier[1][2][3].

  • CAS Number: 1242281-38-4
  • MF: C18H14D5Cl2NO4
  • MW: 389.28
  • Catalog: Autophagy
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 471.5±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 239.0±28.7 °C

UK-52831

UK-52831, a calcium channel antagonist, is used potentially for the treatment of hypertension and myocardia ischemia.

  • CAS Number: 93118-77-5
  • MF: C22H26Cl2N6O5
  • MW: 525.39
  • Catalog: Calcium Channel
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Levoemopamil Hydrochloride

Levemopamil hydrochloride is a blood-brain barrier penetrable calcium channel blocker and a 5-HT2 antagonist. Levemopamil hydrochloride can be used for temporary occlusion and neurological disease research[1].

  • CAS Number: 101238-54-4
  • MF: C23H31ClN2
  • MW: 370.95900
  • Catalog: 5-HT Receptor
  • Density: N/A
  • Boiling Point: 485.8ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 201.1ºC

Trimethadione

Trimethadione is an oxazolidinedione anticonvulsant; commonly used to treat epileptic conditions.

  • CAS Number: 127-48-0
  • MF: C6H9NO3
  • MW: 143.14100
  • Catalog: Calcium Channel
  • Density: 1.171g/cm3
  • Boiling Point: 78-80°C 5mm
  • Melting Point: 45-46°C
  • Flash Point: 78-80°C/5mm

JNJ-26489112

JNJ-26489112 (JNJ26489112) is a broad-spectrum anticonvulsant that displays activity in rodents against audiogenic, electrically-induced, and chemically-induced seizures; exhibits very weak inhibition of human CA-II (IC50=35 μM); inhibits Na+, kainate, and KCNQ2 channels to varying degrees, while moderately potentiating GABA current and inhibiting N-methyl-D-aspartic acid current, its action at several targets appears to be responsible for the observed neurostabilizing effects; shows limited seizure spread and elevated seizure threshold in preclinical animal models. Epilepsy Discontinued

  • CAS Number: 871824-55-4
  • MF: C9H11ClN2O4S
  • MW: 278.713
  • Catalog: Calcium Channel
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 457.8±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 230.7±31.5 °C

BML-278

Flavoxate is a potent and competitive phosphodiesterase (PDE) inhibitor. Flavoxate is an antispasmodic agent and muscarinic mAChR antagonist. Flavoxate shows moderate calcium antagonistic activity and local anesthetic effect. Flavoxate can be used for the research of overactive bladder (OAB) and lower urinary tract infections[1][2].

  • CAS Number: 15301-69-6
  • MF: C24H25NO4
  • MW: 391.460
  • Catalog: mAChR
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 564.1±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 294.9±30.1 °C

Lercanidipine

Lercanidipine is a calcium channel blocker of the dihydropyridine class.Target: Calcium ChannelLercanidipine is a calcium channel blocker of the dihydropyridine class, which works by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body. Lercanidipine was effective and well-tolerated in patients with mild-to-moderate hypertension in the daily practice. The effectiveness and safety of the drug were independent of the degree of cardiovascular risk [1, 2].

  • CAS Number: 100427-26-7
  • MF: C36H41N3O6
  • MW: 611.727
  • Catalog: Calcium Channel
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 712.5±60.0 °C at 760 mmHg
  • Melting Point: 118-120ºC
  • Flash Point: 384.7±32.9 °C

MPC1304

MPC1304 is a Ca2+ channel antagonist with potent and long-lasting antihypertensive effects.

  • CAS Number: 86780-90-7
  • MF: C19H20N2O7
  • MW: 388.37100
  • Catalog: Calcium Channel
  • Density: 1.284 g/cm3
  • Boiling Point: 530ºC at 760 mmHg
  • Melting Point: 155°
  • Flash Point: 274.3ºC

ZSET1446

ZSET1446 is a novel cognitive enhancer that significantly improves learning deficits in various types of Alzheimer disease (AD) models.

  • CAS Number: 887603-94-3
  • MF: C15H12N2O
  • MW: 236.26900
  • Catalog: Calcium Channel
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Catharanthine Tartrate

Catharanthine Tartrate is an alkaloid isolated from Madagascar periwinkle, inhibits voltage-operated L-type Ca2+ channel, with anti-cancer and blood pressure-lowering activity[1].

  • CAS Number: 4168-17-6
  • MF: C46H54N4O10
  • MW: 822.942
  • Catalog: Calcium Channel
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A