Yangambin
Modify Date: 2025-08-25 10:31:20
Yangambin structure
|
Common Name | Yangambin | ||
|---|---|---|---|---|
| CAS Number | 13060-14-5 | Molecular Weight | 446.49000 | |
| Density | 1.183g/cm3 | Boiling Point | 556.1ºC at 760 mmHg | |
| Molecular Formula | C24H30O8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 221.1ºC | |
Use of YangambinYangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca2+ influx through voltage-gated Ca2+ channels, leading to the reduction in [Ca2+]i in vascular smooth muscle cells and consequent peripheral vasodilation[1]. Yangambin exhibits the antiallergic activity against β-hexosaminidase release with an IC50 of 33.8 μM and for anti-inflammatory activity with an IC50 of 37.4 μM[2]. |
| Name | (3S,3aR,6S,6aR)-3,6-bis(3,4,5-trimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan |
|---|---|
| Synonym | More Synonyms |
| Description | Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca2+ influx through voltage-gated Ca2+ channels, leading to the reduction in [Ca2+]i in vascular smooth muscle cells and consequent peripheral vasodilation[1]. Yangambin exhibits the antiallergic activity against β-hexosaminidase release with an IC50 of 33.8 μM and for anti-inflammatory activity with an IC50 of 37.4 μM[2]. |
|---|---|
| Related Catalog | |
| Target |
Ca2+ |
| References |
| Density | 1.183g/cm3 |
|---|---|
| Boiling Point | 556.1ºC at 760 mmHg |
| Molecular Formula | C24H30O8 |
| Molecular Weight | 446.49000 |
| Flash Point | 221.1ºC |
| Exact Mass | 446.19400 |
| PSA | 73.84000 |
| LogP | 3.81340 |
| Vapour Pressure | 7.78E-12mmHg at 25°C |
| Index of Refraction | 1.537 |
| Hazard Codes | Xi |
|---|
| Lirioresinol B dimethyl ether |
| Lirioresinol B,O,O-dimethyl |
| syringaresinol dimethyl ether |
| Lirioresinol B,dimethyl |
| O,O-Dimethyllirioresinol B |