Levoemopamil Hydrochloride

Modify Date: 2024-01-11 17:47:06

Levoemopamil Hydrochloride Structure
Levoemopamil Hydrochloride structure
Common Name Levoemopamil Hydrochloride
CAS Number 101238-54-4 Molecular Weight 370.95900
Density N/A Boiling Point 485.8ºC at 760 mmHg
Molecular Formula C23H31ClN2 Melting Point N/A
MSDS N/A Flash Point 201.1ºC

 Use of Levoemopamil Hydrochloride


Levemopamil hydrochloride is a blood-brain barrier penetrable calcium channel blocker and a 5-HT2 antagonist. Levemopamil hydrochloride can be used for temporary occlusion and neurological disease research[1].

 Names

Name (2S)-5-[methyl(2-phenylethyl)amino]-2-phenyl-2-propan-2-ylpentanenitrile,hydrochloride
Synonym More Synonyms

 Levoemopamil Hydrochloride Biological Activity

Description Levemopamil hydrochloride is a blood-brain barrier penetrable calcium channel blocker and a 5-HT2 antagonist. Levemopamil hydrochloride can be used for temporary occlusion and neurological disease research[1].
Related Catalog
In Vivo Levemopamil hydrochloride (30 mg/kg;腹腔注射,1 次) 可调节双侧颈动脉阻尼 (BCCA) 过程,降低大鼠脑低血症引起的空间记忆障碍[1]。 Animal Model: Male Han-Wistar rats with bilateral damping of carotid arteries (BCCA)[1] Dosage: 30 mg/kg Administration: Intraperitoneal injection; 30 mg/kg, once Result: Showed no effect on GABA or ACh content in either BCCA or sham-operated control rats. Significantly increased swimming speed of BCCA rats in swimming test. Prevented the increasing of escape latency to reach the hidden platform.
References

[1]. Heim C, et al. Levemopamil injection after cerebral oligemia reduces spatial memory deficits in rats. Pharmacol Biochem Behav. 1994 Jul;48(3):613-9.  

 Chemical & Physical Properties

Boiling Point 485.8ºC at 760 mmHg
Molecular Formula C23H31ClN2
Molecular Weight 370.95900
Flash Point 201.1ºC
Exact Mass 370.21800
PSA 27.03000
LogP 5.86068
Vapour Pressure 1.37E-09mmHg at 25°C

 Synonyms

(2S)-5-[methyl(phenethyl)amino]-2-phenyl-2-propan-2-ylpentanenitrile hydrochloride
Levemopamil hydrochloride
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