Levoemopamil Hydrochloride

Levemopamil hydrochloride is a blood-brain barrier penetrable calcium channel blocker and a 5-HT2 antagonist. Levemopamil hydrochloride can be used for temporary occlusion and neurological disease research[1].

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

Levemopamil hydrochloride (30 mg/kg；腹腔注射，1 次) 可调节双侧颈动脉阻尼 (BCCA) 过程，降低大鼠脑低血症引起的空间记忆障碍[1]。 Animal Model: Male Han-Wistar rats with bilateral damping of carotid arteries (BCCA)[1] Dosage: 30 mg/kg Administration: Intraperitoneal injection; 30 mg/kg, once Result: Showed no effect on GABA or ACh content in either BCCA or sham-operated control rats. Significantly increased swimming speed of BCCA rats in swimming test. Prevented the increasing of escape latency to reach the hidden platform.

[1]. Heim C, et al. Levemopamil injection after cerebral oligemia reduces spatial memory deficits in rats. Pharmacol Biochem Behav. 1994 Jul;48(3):613-9.