1,2,4-Trihydroxybenzene

Modify Date: 2025-08-21 12:15:52

1,2,4-Trihydroxybenzene structure	Common Name	1,2,4-Trihydroxybenzene
	CAS Number	533-73-3	Molecular Weight	126.110
	Density	1.5±0.1 g/cm3	Boiling Point	334.5±12.0 °C at 760 mmHg
	Molecular Formula	C₆H₆O₃	Melting Point	140 °C (subl.)(lit.)
	MSDS	Chinese USA	Flash Point	176.9±14.2 °C
	Symbol	GHS05, GHS07	Signal Word	Danger

Use of 1,2,4-Trihydroxybenzene

1,2,4-Trihydroxybenzene (Hydroxyhydroquinone), a by-product of coffee bean roasting, increases intracellular Ca2+ concentration in rat thymic lymphocytes[1].

Name	benzene-1,2,4-triol
Synonym	More Synonyms

Description	1,2,4-Trihydroxybenzene (Hydroxyhydroquinone), a by-product of coffee bean roasting, increases intracellular Ca2+ concentration in rat thymic lymphocytes[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease
References	[1]. Risa Kamae, et al. Hydroxyhydroquinone, a by-product of coffee bean roasting, increases intracellular Ca²⁺ concentration in rat thymic lymphocytes. Food Chem Toxicol. 2017 Apr;102:39-45.

Density	1.5±0.1 g/cm3
Boiling Point	334.5±12.0 °C at 760 mmHg
Melting Point	140 °C (subl.)(lit.)
Molecular Formula	C₆H₆O₃
Molecular Weight	126.110
Flash Point	176.9±14.2 °C
Exact Mass	126.031693
PSA	60.69000
LogP	0.06
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.677
Water Solubility	freely soluble

1,2,4-Trihydroxybenzene MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DC4200000

CHEMICAL NAME :: 1,2,4-Benzenetriol

CAS REGISTRY NUMBER :: 533-73-3

BEILSTEIN REFERENCE NO. :: 2042863

LAST UPDATED :: 199710

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C6-H6-O3

MOLECULAR WEIGHT :: 126.12

WISWESSER LINE NOTATION :: QR BQ DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 122 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 10 umol/L

REFERENCE :: EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 82,81,1989

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H302-H315-H318-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R20/21/22;R36/37/38
Safety Phrases	S26-S39-S36/37/39-S22
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DC4200000
HS Code	2907299090

Precursor 7
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DownStream 10
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HS Code	2907299090
Summary	2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

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Appl. Environ. Microbiol. 78(17) , 6009-16, (2012)

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4-Hydroxycatechol

1,2,4-Trihydroxybenzene

1,2,4-Benzenetriol

1,3,4-Benzenetriol

1,2,3-Trihydroxybenzene

benzene-1,2,3-triol

EINECS 208-575-1

Hydroxyhydroquinone

Benzene-1,2,4-triol

Benzol-1,2,3-triol

1,2,3-Benzenetriol

gallol

4-06-00-07338 (Beilstein Handbook Reference)

MFCD00002198

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 1,2,4-Trihydroxybenzene
Price: Check
Purity: 97.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 1,2,4-Trihydroxybenzene
Price: ￥108.0/5g ￥348.0/25g
Purity: 98.0%
Delivery: 2 Day
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DC Chemicals Limited
China
Product Name: 1,2,4-Trihydroxybenzene
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,2,4-Benzenetriol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Hydroxyhydroquinone
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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