6,7-Dihydroxycoumarin-4-acetic Acid

Modify Date: 2025-08-25 14:17:27

6,7-Dihydroxycoumarin-4-acetic Acid Structure
6,7-Dihydroxycoumarin-4-acetic Acid structure
 Common Name 6,7-Dihydroxycoumarin-4-acetic Acid
CAS Number 88404-14-2 Molecular Weight 236.17800
Density N/A Boiling Point N/A
Molecular Formula C11H8O6 Melting Point 230ºC
MSDS N/A Flash Point N/A

 Use of 6,7-Dihydroxycoumarin-4-acetic Acid


6,7-Dihydroxy-4-coumarinylacetic acid is a potent and selective inhibitor of ALR2. 6,7-Dihydroxy-4-coumarinylacetic acid inhibits ALR2, SDH andALR1 with IC50s of 9.6, 288 and 66.3 μM, respectively. 6,7-Dihydroxy-4-coumarinylacetic acid clearly suppresses galactitol accumulation[1].

 Names

Name 6,7-Dihydroxycoumarin-4-acetic Acid
Synonym More Synonyms

 6,7-Dihydroxycoumarin-4-acetic Acid Biological Activity

Description 6,7-Dihydroxy-4-coumarinylacetic acid is a potent and selective inhibitor of ALR2. 6,7-Dihydroxy-4-coumarinylacetic acid inhibits ALR2, SDH andALR1 with IC50s of 9.6, 288 and 66.3 μM, respectively. 6,7-Dihydroxy-4-coumarinylacetic acid clearly suppresses galactitol accumulation[1].
Related Catalog
References

[1]. Kato A, et al. 6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5630-3.

 Chemical & Physical Properties

Melting Point 230ºC
Molecular Formula C11H8O6
Molecular Weight 236.17800
Exact Mass 236.03200
PSA 107.97000
LogP 0.83130

 Safety Information

Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases 26-36

 Synthetic Route

3-Oxopentanedioic acid structure

3-Oxopentanedio...

CAS#:542-05-2

1,2,4-Trihydroxybenzene structure

1,2,4-Trihydrox...

CAS#:533-73-3

~%

6,7-Dihydroxycoumarin-4-acetic Acid Structure

6,7-Dihydroxyco...

CAS#:88404-14-2

Literature: Journal of the Chemical Society, , vol. 107, p. 1637
3-Oxopentanedioic acid structure

3-Oxopentanedio...

CAS#:542-05-2

1,2,4-Triacetoxybenzene structure

1,2,4-Triacetox...

CAS#:613-03-6

~%

6,7-Dihydroxycoumarin-4-acetic Acid Structure

6,7-Dihydroxyco...

CAS#:88404-14-2

Literature: Annales Pharmaceutiques Francaises, , vol. 7, p. 439

 Synonyms

2-(6,7-dihydroxy-2-oxochromen-4-yl)acetic acid
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Chemsrc provides 6,7-Dihydroxycoumarin-4-acetic Acid(CAS#:88404-14-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 6,7-Dihydroxycoumarin-4-acetic Acid are included as well.>> amp version: 6,7-Dihydroxycoumarin-4-acetic Acid

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