88404-14-2

88404-14-2 structure

Name: 6,7-Dihydroxycoumarin-4-acetic Acid
Chemical Name: 6,7-Dihydroxycoumarin-4-acetic Acid
CAS Number: 88404-14-2
Molecular Formula: C₁₁H₈O₆
Molecular Weight: 236.17800
Catalog: Signaling Pathways Metabolic Enzyme/Protease Aldose Reductase
Create Date: 2018-07-02 14:01:39
Modify Date: 2025-08-25 14:17:27
6,7-Dihydroxy-4-coumarinylacetic acid is a potent and selective inhibitor of ALR2. 6,7-Dihydroxy-4-coumarinylacetic acid inhibits ALR2, SDH andALR1 with IC50s of 9.6, 288 and 66.3 μM, respectively. 6,7-Dihydroxy-4-coumarinylacetic acid clearly suppresses galactitol accumulation[1].

Name	6,7-Dihydroxycoumarin-4-acetic Acid
Synonyms	2-(6,7-dihydroxy-2-oxochromen-4-yl)acetic acid

Description	6,7-Dihydroxy-4-coumarinylacetic acid is a potent and selective inhibitor of ALR2. 6,7-Dihydroxy-4-coumarinylacetic acid inhibits ALR2, SDH andALR1 with IC50s of 9.6, 288 and 66.3 μM, respectively. 6,7-Dihydroxy-4-coumarinylacetic acid clearly suppresses galactitol accumulation[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Aldose Reductase Research Areas >> Metabolic Disease
References	[1]. Kato A, et al. 6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5630-3.

542-05-2

533-73-3

88404-14-2

Literature: Journal of the Chemical Society, , vol. 107, p. 1637

542-05-2

613-03-6

88404-14-2

Literature: Annales Pharmaceutiques Francaises, , vol. 7, p. 439

Precursor 3
542-05-2 533-73-3 613-03-6
DownStream 0