MPC1304
Modify Date: 2024-01-08 19:07:25
MPC1304 structure
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Common Name | MPC1304 | ||
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| CAS Number | 86780-90-7 | Molecular Weight | 388.37100 | |
| Density | 1.284 g/cm3 | Boiling Point | 530ºC at 760 mmHg | |
| Molecular Formula | C19H20N2O7 | Melting Point | 155° | |
| MSDS | N/A | Flash Point | 274.3ºC | |
Use of MPC1304MPC1304 is a Ca2+ channel antagonist with potent and long-lasting antihypertensive effects. |
| Name | 3-O-methyl 5-O-(2-oxopropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
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| Synonym | More Synonyms |
| Description | MPC1304 is a Ca2+ channel antagonist with potent and long-lasting antihypertensive effects. |
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| Related Catalog | |
| Target |
Ca2+ Channel [1] |
| In Vivo | MPC1304 (MPC-1304) is a new Ca2+ channel antagonist in spontaneously hypertensive rats. Following oral administration of MPC1304 at doses of 3 and 10 mg/kg to spontaneously hypertensive rats (SHR), there are significant decreases in Bmax values for specific [3H](+)-PN 200-110 binding to myocardial membranes compared to the control values. The Bmax values at 1 h (3 mg/kg), 1 and 6 h (10 mg/kg) are significantly decreased (47.7, 48.9 and 25.8%, respectively) compared to the control values. The effect is greatest at 1 h and decreases with time. The Bmax values at 6 h (3 mg/kg) and 12 or 24 h (10 mg/kg) after the oral administration of MPC1304 are not significantly different from the control values, suggesting the disappearance of the effect of MPC1304. The Kd values for myocardial [3H](+)-PN 200-110 binding are unaltered by oral administration of MPC1304[1]. |
| Animal Admin | Rats[1] Male SHR (11-15 weeks) are used. They are fasted for 16 h before the administration of drugs, and given MPC1304 (3, 10 mg/kg) orally through a gastric tube. Control animals are given the vehicle. At 1-24 h after drug administration, the SHR are killed by bleeding from the descending aorta under light anesthesia with ethyl ether, and the myocardium and brain are perfused with 0.9% saline from the aorta. Then, both tissues are removed, and blood vessels are trimmed away. Plasma from rat blood is isolated by centrifugation, and stored at -80°C until the concentration of MPC1304 is determined. |
| References |
| Density | 1.284 g/cm3 |
|---|---|
| Boiling Point | 530ºC at 760 mmHg |
| Melting Point | 155° |
| Molecular Formula | C19H20N2O7 |
| Molecular Weight | 388.37100 |
| Flash Point | 274.3ºC |
| Exact Mass | 388.12700 |
| PSA | 127.52000 |
| LogP | 2.98680 |
| Index of Refraction | 1.555 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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~90%
MPC1304 CAS#:86780-90-7 |
| Literature: Ohno; Komatsu; Mizukoshi; Ichihara; Nakamura; Morishima; Sumita Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 4 p. 1589 - 1606 |
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MPC1304 CAS#:86780-90-7 |
| Literature: Chemical and Pharmaceutical Bulletin, , vol. 34, # 4 p. 1589 - 1606 |
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~%
MPC1304 CAS#:86780-90-7 |
| Literature: Chemical and Pharmaceutical Bulletin, , vol. 34, # 4 p. 1589 - 1606 |
|
~%
MPC1304 CAS#:86780-90-7 |
| Literature: Chemical and Pharmaceutical Bulletin, , vol. 34, # 4 p. 1589 - 1606 |
|
~%
MPC1304 CAS#:86780-90-7 |
| Literature: Chemical and Pharmaceutical Bulletin, , vol. 34, # 4 p. 1589 - 1606 |
|
~%
MPC1304 CAS#:86780-90-7 |
| Literature: Chemical and Pharmaceutical Bulletin, , vol. 34, # 4 p. 1589 - 1606 |
|
~%
MPC1304 CAS#:86780-90-7 |
| Literature: Chemical and Pharmaceutical Bulletin, , vol. 34, # 4 p. 1589 - 1606 |
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| MPC1304 |