Methyl acetoacetate

Modify Date: 2024-01-02 08:04:39

Methyl acetoacetate Structure
Methyl acetoacetate structure
 Common Name Methyl acetoacetate
CAS Number 105-45-3 Molecular Weight 116.115
Density 1.0±0.1 g/cm3 Boiling Point 169.4±8.0 °C at 760 mmHg
Molecular Formula C5H8O3 Melting Point -28 °C
MSDS Chinese USA Flash Point 61.6±18.5 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Names

Name Methyl acetoacetate
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 169.4±8.0 °C at 760 mmHg
Melting Point -28 °C
Molecular Formula C5H8O3
Molecular Weight 116.115
Flash Point 61.6±18.5 °C
Exact Mass 116.047340
PSA 43.37000
LogP 0.19
Vapour Pressure 1.5±0.3 mmHg at 25°C
Index of Refraction 1.399
Storage condition 2-8°C
Water Solubility 460 g/L (20 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AK5775000
CHEMICAL NAME :
Acetoacetic acid, methyl ester
CAS REGISTRY NUMBER :
105-45-3
LAST UPDATED :
199701
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C5-H8-O3
MOLECULAR WEIGHT :
116.13
WISWESSER LINE NOTATION :
1V1VO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Open irritation test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 30,63,1948
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 16,815,1978
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3228 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 30,63,1948 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84355 No. of Facilities: 23 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 270 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84355 No. of Facilities: 30 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 1872 (estimated) No. of Female Employees: 336 (estimated)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xi:Irritant
Risk Phrases R36
Safety Phrases S26
WGK Germany 1
RTECS AK5775000
HS Code 2918300090

 Synthetic Route

 Customs

HS Code 2918300090
Summary 2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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 Synonyms

EINECS 203-299-8
Methyl 3-oxobutanoate
Butanoic acid, 3-oxo-, methyl ester
Methyl acetoacetate
3-Oxobutyric acid methyl ester
Acetoacetic Acid Methyl Ester
methyl acetoacetate(MAA)
MFCD00008784
Methyl 3-Oxobutyrate
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