Methyl acetoacetate

Methyl acetoacetate Structure
Methyl acetoacetate structure
Common Name Methyl acetoacetate
CAS Number 105-45-3 Molecular Weight 116.115
Density 1.0±0.1 g/cm3 Boiling Point 169.4±8.0 °C at 760 mmHg
Molecular Formula C5H8O3 Melting Point -28 °C
MSDS Chinese USA Flash Point 61.6±18.5 °C
Symbol GHS07
GHS07
Signal Word Warning

Heparin molecularly imprinted surfaces for the attenuation of complement activation in blood.

Biomater. Sci. 3 , 1208-17, (2015)

Heparin-imprinted synthetic polymer surfaces with the ability to attenuate activation of both the complement and the coagulation system in whole blood were successfully produced. Imprinting was achieved using a template coated with heparin, a highly sulfated ...

Frataxin knockdown in human astrocytes triggers cell death and the release of factors that cause neuronal toxicity.

Neurobiol. Dis. 76 , 1-12, (2015)

Friedreich's ataxia (FA) is a recessive, predominantly neurodegenerative disorder caused in most cases by mutations in the first intron of the frataxin (FXN) gene. This mutation drives the expansion of a homozygous GAA repeat that results in decreased levels ...

Magnetic high throughput screening system for the development of nano-sized molecularly imprinted polymers for controlled delivery of curcumin.

Analyst 140(9) , 3113-20, (2015)

Curcumin is a versatile anti-inflammatory and anti-cancer agent known for its low bioavailability, which could be improved by developing materials capable of binding and releasing drug in a controlled fashion. The present study describes the preparation of ma...

Restricted access molecularly imprinted polymers obtained by bovine serum albumin and/or hydrophilic monomers' external layers: a comparison related to physical and chemical properties.

Analyst 140 , 7768-75, (2015)

Molecularly imprinting polymers (MIPs) can be modified with external layers in order to obtain restricted access molecularly imprinted polymers (RAMIPs) able to exclude macromolecules and retain low weight compounds. These modifications have been frequently a...

Peptide imprinted receptors for the determination of the small cell lung cancer associated biomarker progastrin releasing peptide.

J. Chromatogr. A. 1370 , 56-62, (2014)

Peptide imprinted polymers were developed for detection of progastrin releasing peptide (ProGRP); a low abundant blood based biomarker for small cell lung cancer. The polymers targeted the proteotypic nona-peptide sequence NLLGLIEAK and were used for selectiv...

Improved gate effect enantioselectivity of phenylalanine-imprinted polymers in water by blending crosslinkers.

Anal. Chim. Acta 862 , 77-85, (2015)

In this work, the anodic current at an electrode grafted with a molecularly imprinted polymer (MIP) crosslinked via a combination of hydrophobic ethyleneglycol dimethacrylate (EDMA) and hydrophilic methylene bisacrylamide (MBAA) was found to exhibit enantiose...

Determination of Sudan I in paprika powder by molecularly imprinted polymers-thin layer chromatography-surface enhanced Raman spectroscopic biosensor.

Talanta 143 , 344-52, (2015)

Sudan I is a carcinogenic and mutagenic azo-compound that has been utilized as a common adulterant in spice and spice blends to impart a desirable red color to foods. A novel biosensor combining molecularly imprinted polymers (MIPs), thin layer chromatography...

In vitro inhibition of protease-activated receptors 1, 2 and 4 demonstrates that these receptors are not involved in an Acanthamoeba castellanii keratitis isolate-mediated disruption of the human brain microvascular endothelial cells.

Exp. Parasitol. 145 Suppl , S78-83, (2014)

Granulomatous amoebic encephalitis is a rare but serious human disease leading almost always to death. The pathophysiology of amoebic encephalitis is better understood, while events leading to the constitution of brain infection are largely unknown. Traversal...

Synthesis of poly(meth)acrylates with thioether and tertiary sulfonium groups by ARGET ATRP and their use as siRNA delivery agents.

Biomacromolecules 16(1) , 236-45, (2015)

The field of RNA interference depends on the development of safe and efficient carriers for short interfering ribonucleic acid (siRNA) delivery. Conventional cationic monomers for siRNA delivery have utilized the nitrogen heteroatom to produce cationic charge...

Investigation of resins suitable for the preparation of biological sample for 3-D electron microscopy.

J. Struct. Biol. 189(2) , 135-46, (2015)

In the last two decades, the third-dimension has become a focus of attention in electron microscopy to better understand the interactions within subcellular compartments. Initially, transmission electron tomography (TEM tomography) was introduced to image the...