Azido-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Fabiatrin is a natural product isolated from Przewalskia tangutica[1].
NH-bis(C1-Boc)is a uncleavable linker used for antibody-drug conjugates (ADC).
Pseudojervine is a glycoalkaloid with a feeble inhibition activity against platelet aggregation[1].
GDP366, a dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells.
N1-Propargylpseudouridine (see GL102032) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
VEGFR-2-IN-21 (Compound 5d) is a potent VEGFR-2 inhibitor with an IC50 of 0.10 μM. VEGFR-2-IN-21 shows anticancer activity[1].
6α-Hydroxypolyporenic acid C, a lanostane triterpenoid, is a nature product that could be isolated from the sclerotium of Poria cocos. 6α-Hydroxypolyporenic acid C can be absorbed across intestinal epithelial cells[1].
Human β-defensin-1 (HβD-1) is a cysteine-rich cationic skin-antimicrobial peptide (SAP) produced by all epithelial surfaces, but also by circulatory cells and cells of the reproductive tract. Human β-defensin-1 has antimicrobial activities against a broad-sperm bacteria[1].
Met-Gly-Pro-AMC is a fluorescent peptide substrate of MetAP2[1].
Dihydroconiferyl alcohol is a cell division factor that can be found in pring sap of Acer pseudoplatanus L. Dihydroconiferyl alcohol can stimulate growth of soybean callus[1].
Massarilactone H, a polyketide, is a neuraminidase inhibitor, with an IC50 of 8.18 µM[1].
(R)-2-Amino-3-(3-(trifluoromethyl)phenyl)propanoic acid is a phenylalanine derivative[1].
11-O-β-D-glucopyranosyl thamnosmonin, a coumarin glucosides, can be isolated from the roots of Angelica apaensis. 11-O-β-D-glucopyranosyl thamnosmonin has weak inhibitory activity on the aggregation of rabbit platelets induced by PAF, AA, and ADP[1].
Sipatrigine, a neuroprotective agent, is a glutamate release inhibitor, voltage-dependent sodium channel and calcium channel inhibitor, penetrating the central nervous system. Has potential to treat focal cerebral ischemia and stroke[1][2].
Dimethyl adipate-d4-1 is the deuterium labeled Dimethyl adipate[1].
BMS-903452 is a potent and selective GPR119 agonist for diabetes research[1].
3-Aminopropan-1-ol-d6 is the deuterium labeled 3-Aminopropan-1-ol[1].
Isovalerylcarnitine-d9 (chloride) is the deuterium labeled Isovalerylcarnitine (chloride)[1]. Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca2+-dependent proteinase (calpain) of human neutrophils[2].
Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity[1]. Phloracetophenone stimulats bile secretion mediated through Mrp2[2].
ELA-21 (human) is an apelin receptor agonist with a pKi of 8.52. ELA-21 (human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment with subnanomolar potencies. ELA-21 (human) is an agonist in G-protein-dependent and -independent pathways[1].
Interiorin can be isolated from Kadsura heteroclita and has moderate anti-HIV activity with an EC50 value of 1.6 lg/mL[1].
JH-VIII-157-02 is a structural analogue of alectinib, acts as an ALK inhibitor, and shows an IC50 of 2 nM for echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) G1202R in cells.
Anilofos is a pre-emergence, organophosphorus herbicide. Anilofos has moderate toxic potential in mammals[1].
Idarucizumab is a humanized monoclonal antibody fragment. Idarucizumab is first reversal agent for a direct oral anticoagulant (DOAC). Idarucizumab can specifically neutralize the effects of the oral direct thrombin inhibitor in order to restore hemostasis[1].
NOD2 antagonist 1 (compound 32) is a potent and selective NOD2 antagonist with an IC50 of 5.23 μM. NOD2 antagonist 1 inhibits Muramyl dipeptide (MDP)-induced IL-8 secretion in THP-1 cells and inhibits MDP-induced IL-6, IL-10, TNF-α release in PBMCs[1].
Fmoc-Ser(PO(NHPr)2)-OH is a serine derivative[1].
Fmoc-Ser-Obzl is a serine derivative[1].
Isomogroside V is a sweetener, which extracted from Siraitia grosvenorii (Swingle).
Nemorosone is the main component of the floral resin of Clusia rosea. Nemorosone has an antiproliferative effect on cancer cells. Nemorosone induces apoptosis in HT-29 and LoVo cells[1][2].