480-66-0

480-66-0 structure

Name: 2',4',6'-Trihydroxyacetophenone Monohydrate
Chemical Name: 2',4',6'-trihydroxyacetophenone
CAS Number: 480-66-0
Molecular Formula: C₈H₈O₄
Molecular Weight: 168.147
Catalog: Chemical reagent Organic reagent Aromatic ketone
Create Date: 2018-12-25 17:12:51
Modify Date: 2024-01-03 00:52:00
Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity[1]. Phloracetophenone stimulats bile secretion mediated through Mrp2[2].

Name	2',4',6'-trihydroxyacetophenone
Synonyms	1-(2,4,6-Trihydroxyphenyl)-ethanone 2-Acetylphloroglucinol EINECS 207-556-5 Ethanone, 1- (2,4,6-trihydroxyphenyl)- 2-Acetylphloroglucinol Monohydrate Phloroacetophenone Ethanone, 1-(2,4,6-trihydroxyphenyl)- 2',4',6'-Trihydroxyacetophenone Monohydrate 2-Acetylphloroglucinol,THAP 2',4',6'-Trihydroxyaceto-phenone 2,4,6-trihydroxyacetophenone Phloroacetophenone Monohydrate 1-(2,4,6-Trihydroxyphenyl)ethanone MFCD00002287 Phloracetophenone

Description	Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity[1]. Phloracetophenone stimulats bile secretion mediated through Mrp2[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others Natural Products >> Phenols
Target	Cholesterol 7α-hydroxylase[1], Mrp2[2]
In Vitro	Phloracetophenone (2,4,6-trihydroxyacetophenone) is a cholesterol-lowering agent, enhances cholesterol 7α-hydroxylase (CYP7A1) activity, and elevates CYP7A1 mRNA level[1]. Phloracetophenone (1, 2, and 4 μmol/min) immediately and dose-dependently increases bile acid-independent bile flow in the isolated perfused rat liver[2].
In Vivo	Phloracetophenone (2,4,6-trihydroxyacetophenone; 125 or 250 μmol/kg, intraduodenal injection) shows choleretic activity requiring multidrug resistance protein-2 (Mrp2) in rats. Phloracetophenone (40 μmol/min) partially prevents the E2-17G induced cholestasis[2].
References	[1]. Charoenteeraboon J, et al. Induction of human cholesterol 7alpha-hydroxylase in HepG2 cells by 2,4,6-trihydroxyacetophenone. Eur J Pharmacol. 2005 May 16;515(1-3):43-6. [2]. Piyachaturawat P, et al. Choleretic activity of phloracetophenone in rats: structure-function studies using acetophenone analogues. Eur J Pharmacol. 2000 Jan 10;387(2):221-7.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AN0528000
HS Code	2942000000

HS Code	2914501900
Summary	2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%