2',4',6'-Trihydroxyacetophenone Monohydrate

Modify Date: 2024-01-03 00:52:00

2',4',6'-Trihydroxyacetophenone Monohydrate Structure
2',4',6'-Trihydroxyacetophenone Monohydrate structure
 Common Name 2',4',6'-Trihydroxyacetophenone Monohydrate
CAS Number 480-66-0 Molecular Weight 168.147
Density 1.4±0.1 g/cm3 Boiling Point 333.2±22.0 °C at 760 mmHg
Molecular Formula C8H8O4 Melting Point 219-221 °C(lit.)
MSDS Chinese USA Flash Point 169.5±18.8 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of 2',4',6'-Trihydroxyacetophenone Monohydrate


Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity[1]. Phloracetophenone stimulats bile secretion mediated through Mrp2[2].

 Names

Name 2',4',6'-trihydroxyacetophenone
Synonym More Synonyms

  Biological Activity

Description Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity[1]. Phloracetophenone stimulats bile secretion mediated through Mrp2[2].
Related Catalog
Target

Cholesterol 7α-hydroxylase[1], Mrp2[2]
In Vitro Phloracetophenone (2,4,6-trihydroxyacetophenone) is a cholesterol-lowering agent, enhances cholesterol 7α-hydroxylase (CYP7A1) activity, and elevates CYP7A1 mRNA level[1]. Phloracetophenone (1, 2, and 4 μmol/min) immediately and dose-dependently increases bile acid-independent bile flow in the isolated perfused rat liver[2].
In Vivo Phloracetophenone (2,4,6-trihydroxyacetophenone; 125 or 250 μmol/kg, intraduodenal injection) shows choleretic activity requiring multidrug resistance protein-2 (Mrp2) in rats. Phloracetophenone (40 μmol/min) partially prevents the E2-17G induced cholestasis[2].
References

[1]. Charoenteeraboon J, et al. Induction of human cholesterol 7alpha-hydroxylase in HepG2 cells by 2,4,6-trihydroxyacetophenone. Eur J Pharmacol. 2005 May 16;515(1-3):43-6.

[2]. Piyachaturawat P, et al. Choleretic activity of phloracetophenone in rats: structure-function studies using acetophenone analogues. Eur J Pharmacol. 2000 Jan 10;387(2):221-7.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 333.2±22.0 °C at 760 mmHg
Melting Point 219-221 °C(lit.)
Molecular Formula C8H8O4
Molecular Weight 168.147
Flash Point 169.5±18.8 °C
Exact Mass 168.042252
PSA 77.76000
LogP 2.07
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.641
Storage condition Refrigerator

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S36-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS AN0528000
HS Code 2942000000

 Synthetic Route

 Customs

HS Code 2914501900
Summary 2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

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 Synonyms

1-(2,4,6-Trihydroxyphenyl)-ethanone
2-Acetylphloroglucinol
EINECS 207-556-5
Ethanone, 1- (2,4,6-trihydroxyphenyl)-
2-Acetylphloroglucinol Monohydrate
Phloroacetophenone
Ethanone, 1-(2,4,6-trihydroxyphenyl)-
2',4',6'-Trihydroxyacetophenone Monohydrate
2-Acetylphloroglucinol,THAP
2',4',6'-Trihydroxyaceto-phenone
2,4,6-trihydroxyacetophenone
Phloroacetophenone Monohydrate
1-(2,4,6-Trihydroxyphenyl)ethanone
MFCD00002287
Phloracetophenone
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Chemsrc provides CAS#:480-66-0 MSDS, density, melting point, boiling point, structure, etc. Its name is 2',4',6'-Trihydroxyacetophenone Monohydrate>> amp version: 2',4',6'-Trihydroxyacetophenone Monohydrate

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