Flavokawain A

Modify Date: 2024-01-02 17:58:04

Flavokawain A Structure
Flavokawain A structure
Common Name Flavokawain A
CAS Number 3420-72-2 Molecular Weight 314.332
Density 1.2±0.1 g/cm3 Boiling Point 529.9±50.0 °C at 760 mmHg
Molecular Formula C18H18O5 Melting Point 112-116 °C(lit.)
MSDS Chinese USA Flash Point 193.2±23.6 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Flavokawain A


Flavokawain A, a proming anticarcinogenic agent, is a chalcone from kava extract with anti-tumor activity. Flavokawain A induces cell apoptosis by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway. Flavokawain A has the potential for the study of bladder cancer[1].

 Names

Name 2'-hydroxy-4,4',6'-trimethoxychalcone
Synonym More Synonyms

 Flavokawain A Biological Activity

Description Flavokawain A, a proming anticarcinogenic agent, is a chalcone from kava extract with anti-tumor activity. Flavokawain A induces cell apoptosis by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway. Flavokawain A has the potential for the study of bladder cancer[1].
Related Catalog
References

[1]. Xiaolin Zi, et al. Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice. Cancer Res. 2005 Apr 15;65(8):3479-86.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 529.9±50.0 °C at 760 mmHg
Melting Point 112-116 °C(lit.)
Molecular Formula C18H18O5
Molecular Weight 314.332
Flash Point 193.2±23.6 °C
Exact Mass 314.115417
PSA 64.99000
LogP 3.96
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.600

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2914509090

 Synthetic Route

~82%

Flavokawain A Structure

Flavokawain A

CAS#:3420-72-2

Literature: Singh, Om V.; Muthukrishnan; Sunderavadivelu Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 12 p. 2575 - 2581

~89%

Flavokawain A Structure

Flavokawain A

CAS#:3420-72-2

Literature: Lee, Yean-Jang; Wu, Tsao-Dong Journal of the Chinese Chemical Society, 2001 , vol. 48, # 2 p. 201 - 206

~36%

Flavokawain A Structure

Flavokawain A

CAS#:3420-72-2

Literature: Lee, Yean-Jang; Wu, Tsao-Dong Journal of the Chinese Chemical Society, 2001 , vol. 48, # 2 p. 201 - 206

~49%

Flavokawain A Structure

Flavokawain A

CAS#:3420-72-2

Literature: Smith, Jeffrey A.; Maloney, David J.; Hecht, Sidney M.; Lannigan, Deborah A. Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 14 p. 5018 - 5034

~%

Flavokawain A Structure

Flavokawain A

CAS#:3420-72-2

Literature: Journal of Agricultural and Food Chemistry, , vol. 48, # 5 p. 1888 - 1891

~%

Flavokawain A Structure

Flavokawain A

CAS#:3420-72-2

Literature: Journal of the Chinese Chemical Society, , vol. 48, # 2 p. 201 - 206

~%

Flavokawain A Structure

Flavokawain A

CAS#:3420-72-2

Literature: Journal of the Chinese Chemical Society, , vol. 48, # 2 p. 201 - 206

~%

Flavokawain A Structure

Flavokawain A

CAS#:3420-72-2

Literature: Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 26, p. 57 - 58

 Customs

HS Code 2914509090
Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

 Synonyms

FLAVOKAWIN A
1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one
Flavokavin A
MFCD00017174
2'-Hydroxy-4,4',6'-trimethoxy-trans-chalcone
2'-Hydroxy-4,4',6'-trimethoxy
flavokawain-A
2'-hydroxy-4',6'-dimethoxyphenyl-4-methoxystyrylketone
2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-
2'-hydroxy-4,4',6'-trimethoxy-chalcone
Flavokawain A
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  • Product Name: Flavokawain A
  • Price: ¥Inquiry/10mg
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Xueping-Zheng




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