Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Nemorosone
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351416-47-2

351416-47-2 structure

351416-47-2 structure

Name: Nemorosone
Chemical Name: Nemorosone
CAS Number: 351416-47-2
Molecular Formula: C₃₃H₄₂O₄
Molecular Weight: 502.684
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2021-08-27 08:08:39
Modify Date: 2024-01-11 16:41:27
Nemorosone is the main component of the floral resin of Clusia rosea. Nemorosone has an antiproliferative effect on cancer cells. Nemorosone induces apoptosis in HT-29 and LoVo cells[1][2].

Name	Nemorosone
Synonyms	(1R,5S,7S)-5-Benzoyl-4-hydroxy-6,6-dimethyl-1,3,7-tris(3-methyl-2-buten-1-yl)bicyclo[3.3.1]non-3-ene-2,9-dione Bicyclo[3.3.1]non-3-ene-2,9-dione, 5-benzoyl-4-hydroxy-6,6-dimethyl-1,3,7-tris(3-methyl-2-buten-1-yl)-, (1R,5S,7S)- Nemorosone

Description	Nemorosone is the main component of the floral resin of Clusia rosea. Nemorosone has an antiproliferative effect on cancer cells. Nemorosone induces apoptosis in HT-29 and LoVo cells[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
Target	apoptosis[1]
In Vitro	Nemorosone (0-50 μM; 24-72 h) inhibits the proliferation of HT-29 and LoVo cells with IC50s of 25.7-27.1 μM, 22.8-64.3 μM, respectively[1]. Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) increases the percentage of G0/G1 phase cells[1]. Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) induces apoptosis in both cell lines[1]. Cell Proliferation Assay[1] Cell Line: HT-29 and LoVo cells Concentration: 0-50 μM Incubation Time: 24-72 h Result: Inhibited the proliferation of HT-29 and LoVo cells with IC50s of 25.7-27.1 μM, 22.8-64.3 μM, respectively. Cell Cycle Analysis[1] Cell Line: HT-29 and LoVo cells Concentration: 25.7 μM for HT-29; 22.8 μM for LoVo Incubation Time: 24, 48 hours Result: Increased the percentage of G0/G1 phase cells. Apoptosis Analysis[1] Cell Line: HT-29 and LoVo cells Concentration: 25.7 μM for HT-29; 22.8 μM for LoVo Incubation Time: 24, 48 hours Result: Induced apoptosis in both cell lines.
In Vivo	Nemorosone (50 mg/kg; daily i.p. for 28 days) shows a significant growth-inhibitory effect in pancreatic cancer xenografts[2]. Animal Model: Athymic NMRI nu/nu nude mices (6 to 8 week old female), which had 100 mm3 MIA-PaCa-2 xenograft tumor[2] Dosage: 50 mg/kg Administration: Daily i.p. injections for 28 days Result: Showed a significant growth-inhibitory effect in pancreatic cancer xenografts[2].
References	[1]. Frión-Herrera Y, Gabbia D, Scaffidi M, et al. The Cuban Propolis Component Nemorosone Inhibits Proliferation and Metastatic Properties of Human Colorectal Cancer Cells. Int J Mol Sci. 2020;21(5):1827. Published 2020 Mar 6. [2]. Wolf RJ, et al. In vivo activity and pharmacokinetics of nemorosone on pancreatic cancer xenografts. PLoS One. 2013;8(9):e74555. Published 2013 Sep 5.

Density	1.1±0.1 g/cm3
Boiling Point	608.9±55.0 °C at 760 mmHg
Molecular Formula	C₃₃H₄₂O₄
Molecular Weight	502.684
Flash Point	336.1±28.0 °C
Exact Mass	502.308319
LogP	10.69
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.553