2245073-05-4

2245073-05-4 structure

Name: ELA-21 (human)
Chemical Name: ELA-21 (human)
CAS Number: 2245073-05-4
Molecular Formula: C₁₁₂H₁₈₄N₄₀O₂₅S₃
Molecular Weight: 2587.14
Catalog: Research Areas Cardiovascular Disease
Create Date: 2020-08-10 20:51:44
Modify Date: 2024-01-05 19:19:21
ELA-21 (human) is an apelin receptor agonist with a pKi of 8.52. ELA-21 (human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment with subnanomolar potencies. ELA-21 (human) is an agonist in G-protein-dependent and -independent pathways[1].

Name	ELA-21 (human)

Description	ELA-21 (human) is an apelin receptor agonist with a pKi of 8.52. ELA-21 (human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment with subnanomolar potencies. ELA-21 (human) is an agonist in G-protein-dependent and -independent pathways[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
References	[1]. Peiran Yang, et al. Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension. Circulation. 2017 Mar 21;135(12):1160-1173.

Molecular Formula	C₁₁₂H₁₈₄N₄₀O₂₅S₃
Molecular Weight	2587.14