1334532-23-8

1334532-23-8 structure

Name: Isovalerylcarnitine-d9 chloride
Chemical Name: Isovaleryl L-Carnitine-d9 Chloride
CAS Number: 1334532-23-8
Molecular Formula: C₁₂H₁₅D₉ClNO₄
Molecular Weight: 290.83
Catalog: Signaling Pathways Metabolic Enzyme/Protease Proteasome
Create Date: 2022-05-20 13:38:31
Modify Date: 2025-09-02 10:40:46
Isovalerylcarnitine-d9 (chloride) is the deuterium labeled Isovalerylcarnitine (chloride)[1]. Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca2+-dependent proteinase (calpain) of human neutrophils[2].

Name	Isovaleryl L-Carnitine-d9 Chloride
Synonyms	(2R)-3-Carboxy-N,N,N-trimethyl-2-(3-methyl-1-oxobutoxy)-1-propanaminium-d9 Chloride (2R)-3-Carboxy-N,N,N-tris[(2H3)methyl]-2-[(3-methylbutanoyl)oxy]-1-propanaminium chloride 1-Propanaminium, 3-carboxy-N,N,N-tri(methyl-d3)-2-(3-methyl-1-oxobutoxy)-, chloride (1:1), (2R)- 1-Propanaminium, 3-carboxy-N,N,N-tri(methyl-d3)-2-(3-methyl-1-oxobutoxy)-, chloride, (2R)- (1:1) (R)-3-Carboxy-N,N,N-trimethyl-2-(3-methyl-1-oxobutoxy)-1-propanaminium-d9 Chloride

Description	Isovalerylcarnitine-d9 (chloride) is the deuterium labeled Isovalerylcarnitine (chloride)[1]. Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca2+-dependent proteinase (calpain) of human neutrophils[2].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Pontremoli S, et al. Isovalerylcarnitine is a specific activator of calpain of human neutrophils. Biochem Biophys Res Commun. 1987 Nov 13;148(3):1189-95.