Chemsrc provides Others's classification. They are divided into Androgen Receptor, Aromatase, Estrogen Receptor/ERR, Progesterone Receptor, Thyroid Hormone Receptor, Others according to their Biological activity.


Anti-infection >
Arenavirus Bacterial CMV Enterovirus Filovirus Fungal HBV HCV HIV HSV Influenza Virus Parasite Reverse Transcriptase RSV SARS-CoV
Antibody-drug Conjugate >
ADC Cytotoxin ADC Linker Drug-Linker Conjugates for ADC PROTAC-linker Conjugate for PAC
Apoptosis >
Apoptosis Bcl-2 Family c-Myc Caspase DAPK Ferroptosis IAP MDM-2/p53 PKD RIP kinase Survivin Thymidylate Synthase TNF Receptor
Autophagy >
Autophagy LRRK2 ULK Mitophagy
Cell Cycle/DNA Damage >
Antifolate APC ATM/ATR Aurora Kinase Casein Kinase CDK Checkpoint Kinase (Chk) CRISPR/Cas9 Deubiquitinase DNA Alkylator/Crosslinker DNA-PK DNA/RNA Synthesis Eukaryotic Initiation Factor (eIF) G-quadruplex Haspin Kinase HDAC HSP IRE1 Kinesin LIM Kinase (LIMK) Microtubule/Tubulin Mps1 Nucleoside Antimetabolite/Analog p97 PAK PARP PERK Polo-like Kinase (PLK) PPAR RAD51 ROCK Sirtuin SRPK Telomerase TOPK Topoisomerase Wee1
Cytoskeleton >
Arp2/3 Complex Dynamin Gap Junction Protein Integrin Kinesin Microtubule/Tubulin Mps1 Myosin PAK
Epigenetics >
AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain HDAC Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MicroRNA PARP PKC Sirtuin Protein Arginine Deiminase
GPCR/G Protein >
5-HT Receptor Adenosine Receptor Adenylate Cyclase Adiponectin Receptor Adrenergic Receptor Angiotensin Receptor Bombesin Receptor Bradykinin Receptor Cannabinoid Receptor CaSR CCR CGRP Receptor Cholecystokinin Receptor CRFR CXCR Dopamine Receptor EBI2/GPR183 Endothelin Receptor GHSR Glucagon Receptor Glucocorticoid Receptor GNRH Receptor GPCR19 GPR109A GPR119 GPR120 GPR139 GPR40 GPR55 GPR84 Guanylate Cyclase Histamine Receptor Imidazoline Receptor Leukotriene Receptor LPL Receptor mAChR MCHR1 (GPR24) Melatonin Receptor mGluR Motilin Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor Opioid Receptor Orexin Receptor (OX Receptor) Oxytocin Receptor P2Y Receptor Prostaglandin Receptor Protease-Activated Receptor (PAR) Ras RGS Protein Sigma Receptor Somatostatin Receptor TSH Receptor Urotensin Receptor Vasopressin Receptor Melanocortin Receptor
Immunology/Inflammation >
Aryl Hydrocarbon Receptor CCR Complement System COX CXCR FLAP Histamine Receptor IFNAR Interleukin Related IRAK MyD88 NO Synthase NOD-like Receptor (NLR) PD-1/PD-L1 PGE synthase Salt-inducible Kinase (SIK) SPHK STING Thrombopoietin Receptor Toll-like Receptor (TLR) Arginase
JAK/STAT Signaling >
EGFR JAK Pim STAT
MAPK/ERK Pathway >
ERK JNK KLF MAP3K MAP4K MAPKAPK2 (MK2) MEK Mixed Lineage Kinase MNK p38 MAPK Raf Ribosomal S6 Kinase (RSK)
Membrane Transporter/Ion Channel >
ATP Synthase BCRP Calcium Channel CFTR Chloride Channel CRAC Channel CRM1 EAAT2 GABA Receptor GlyT HCN Channel iGluR Monoamine Transporter Monocarboxylate Transporter Na+/Ca2+ Exchanger Na+/HCO3- Cotransporter Na+/K+ ATPase nAChR NKCC P-glycoprotein P2X Receptor Potassium Channel Proton Pump SGLT Sodium Channel TRP Channel URAT1
Metabolic Enzyme/Protease >
15-PGDH 5 alpha Reductase 5-Lipoxygenase Acetyl-CoA Carboxylase Acyltransferase Adenosine Deaminase Adenosine Kinase Aldehyde Dehydrogenase (ALDH) Aldose Reductase Aminopeptidase Angiotensin-converting Enzyme (ACE) ATGL ATP Citrate Lyase Carbonic Anhydrase Carboxypeptidase Cathepsin CETP COMT Cytochrome P450 Dipeptidyl Peptidase Dopamine β-hydroxylase E1/E2/E3 Enzyme Elastase Enolase FAAH FABP Factor Xa Farnesyl Transferase Fatty Acid Synthase (FAS) FXR Glucokinase GSNOR Gutathione S-transferase HCV Protease Hexokinase HIF/HIF Prolyl-Hydroxylase HIV Integrase HIV Protease HMG-CoA Reductase (HMGCR) HSP Indoleamine 2,3-Dioxygenase (IDO) Isocitrate Dehydrogenase (IDH) Lactate Dehydrogenase LXR MAGL Mineralocorticoid Receptor Mitochondrial Metabolism MMP Nampt NEDD8-activating Enzyme Neprilysin PAI-1 PDHK PGC-1α Phosphatase Phosphodiesterase (PDE) Phospholipase Procollagen C Proteinase Proteasome Pyruvate Kinase RAR/RXR Renin ROR Ser/Thr Protease SGK Stearoyl-CoA Desaturase (SCD) Thrombin Tryptophan Hydroxylase Tyrosinase Xanthine Oxidase
Neuronal Signaling >
5-HT Receptor AChE Adenosine Kinase Amyloid-β Beta-secretase CaMK CGRP Receptor COMT Dopamine Receptor Dopamine Transporter FAAH GABA Receptor GlyT iGluR Imidazoline Receptor mAChR Melatonin Receptor Monoamine Oxidase nAChR Neurokinin Receptor Opioid Receptor Serotonin Transporter γ-secretase
NF-κB >
NF-κB IKK Keap1-Nrf2 MALT1
PI3K/Akt/mTOR >
Akt AMPK ATM/ATR DNA-PK GSK-3 MELK mTOR PDK-1 PI3K PI4K PIKfyve PTEN
PROTAC >
PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase PROTAC Linker PROTAC-linker Conjugate for PAC
Protein Tyrosine Kinase/RTK >
Ack1 ALK Bcr-Abl BMX Kinase Btk c-Fms c-Kit c-Met/HGFR Discoidin Domain Receptor DYRK EGFR Ephrin Receptor FAK FGFR FLT3 IGF-1R Insulin Receptor IRAK Itk PDGFR PKA Pyk2 ROS Src Syk TAM Receptor Trk Receptor VEGFR
Stem Cell/Wnt >
Casein Kinase ERK Gli GSK-3 Hedgehog Hippo (MST) JAK Notch Oct3/4 PKA Porcupine ROCK sFRP-1 Smo STAT TGF-beta/Smad Wnt YAP β-catenin γ-secretase
TGF-beta/Smad >
TGF-beta/Smad PKC ROCK TGF-β Receptor
Vitamin D Related >
VD/VDR
Others >
Androgen Receptor Aromatase Estrogen Receptor/ERR Progesterone Receptor Thyroid Hormone Receptor Others

Nocarimidazole A

Nocarimidazole A is a white amorphous solid alkaloid with ultraviolet activity found from marine actinomycete Nocardiopsis[1][2].

  • CAS Number: 1818218-33-5
  • MF: C13H23N3O
  • MW: 237.34
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

(-)-lariciresinol

(-)-Lariciresinol is a lignans that can be isolated from Sambucus williamsii. (-)-Lariciresinol stimulates UMR106 cell proliferation[1].

  • CAS Number: 83327-19-9
  • MF: C20H24O6
  • MW: 360.40
  • Catalog: Cancer
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

α-Amylase-IN-3

α-Amylase-IN-3 (Compound 4) is a none-competitive type of α-Amylase inhibitor with an IC50 value of 18.04 μM, which also has radical scavenging activities (DPPH and ABTS) with IC50 values of 16.04 μM (DPPH) and 16.99 μM (ABTS), respectively. α-Amylase-IN-3 has good protein–ligand interactions profile against α-Amylase. α-Amylase-IN-3 may have pharmacological activities such as anti-oxidative, anti-inflammatory inhibitory, which is helpful for the development of diabetes and oxidative stress associated disease[1].

  • CAS Number: 93944-58-2
  • MF: C15H9NO4
  • MW: 267.24
  • Catalog: Cancer
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Edetol

Quadrol is an immunostimulant and has been implicated as a potentially useful agent in accelerated wound healing.

  • CAS Number: 102-60-3
  • MF: C14H32N2O4
  • MW: 292.415
  • Catalog: Inflammation/Immunology
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 369.1±0.0 °C at 760 mmHg
  • Melting Point: 32°C
  • Flash Point: 145.7±17.4 °C

UNII:5K6L8O868Y

4'-Hydroxyflavanone is an inhibitor of SREBP maturation and lipid synthesis. 4'-Hydroxyflavanone is a synthetic analogue of flavanone, has potential for hepatic steatosis and dyslipidemia research[1].

  • CAS Number: 6515-37-3
  • MF: C15H12O3
  • MW: 240.25
  • Catalog: Metabolic Disease
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 447.5±45.0 °C at 760 mmHg
  • Melting Point: 182°C
  • Flash Point: 174.0±22.2 °C

1-epi-Regadenoson hydrazone

1-epi-Regadenoson hydrazone is an intermediate in the synthesis of αisomer impurity of Regadenoson which is a highly selective adenosine A2A receptor agonist[1].

  • CAS Number: 2015222-41-8
  • MF: C10H15N7O4
  • MW: 297.27
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Boc-D-alanine N-hydroxy succinimide ester

Boc-D-Ala-OSu is an alanine derivative[1].

  • CAS Number: 34404-33-6
  • MF: C12H18N2O6
  • MW: 286.281
  • Catalog: Others
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

MIF-IN-2

MIF-IN-2 is a migration inhibitory factor (MIF) inhibitor extracted from patent WO2021258272A1 compound 1. MIF-IN-2 can be used for the research of immune inflammation-related diseases[1].

  • CAS Number: 2756410-57-6
  • MF: C14H10ClN3O4
  • MW: 319.70
  • Catalog: Inflammation/Immunology
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

helospectin I

Helospectin I is a neuropeptide of the vasoactive intestinal peptide (VIP) family. Helospectin I has vasodilatory and antihypertensive activities, and decreases blood pressure. Helospectin I is originally isolated from the salivary gland venom of the lizard Heloderma suspectum[1][2].

  • CAS Number: 93438-37-0
  • MF: C183H293N47O59
  • MW:
  • Catalog: Cardiovascular Disease
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Rosiglitazone-d5 Maleate

Rosiglitazone-d5 (maleate) is the deuterium labeled Rosiglitazone maleate[1].

  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

CTP Inhibitor

CTP inhibitor is a potent and selective CTP inhibitor. CTP inhibitor inhibits the plasma membrane citrate transporter (PMCT)[1].

  • CAS Number: 412940-35-3
  • MF: C13H9ClN2O6S
  • MW: 356.73800
  • Catalog: Metabolic Disease
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Estrogen receptor β antagonist 2

Estrogen receptor β antagonist 2 is a potent and selective estrogen receptor β (ERβ) antagonist with IC50s of 109.10, 0.63 µM for Erα and Erβ, respectively[1].

  • CAS Number: 2580941-14-4
  • MF: C23H26N2O6
  • MW: 426.46
  • Catalog: Cancer
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Boc-Cys(Bzl)-OH

(R)-3-(Benzylthio)-2-((tert-butoxycarbonyl)amino)propanoic acid is a cysteine derivative[1].

  • CAS Number: 5068-28-0
  • MF: C15H21NO4S
  • MW: 311.397
  • Catalog: Others
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 481.2±45.0 °C at 760 mmHg
  • Melting Point: 86-88 °C
  • Flash Point: 244.8±28.7 °C

ARTOCARPIN

Artocarpin is an isoprenoid-substituted flavonoid, that can be isolated from the wood of Artocarpus heterophyllus. Artocarpin inhibits melanin biosynthesis in B16 melanoma cells without inhibiting tyrosinase. The presence of the isoprenoid-substituted moiety enhanced the inhibitory activity on melanin production in B16 melanoma cells[1].

  • CAS Number: 7608-44-8
  • MF: C26H28O6
  • MW: 436.50
  • Catalog: Cancer
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 651.7±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 219.9±25.0 °C

GB-2a

GB-2a is a bioflavonoids that can be isolated from Rheedia gardneriana. GB-2a has significant analgesic activity in mice with 58.9% inhibition[1].

  • CAS Number: 18412-96-9
  • MF: C30H22O11
  • MW: 558.48900
  • Catalog: Inflammation/Immunology
  • Density: 1.643g/cm3
  • Boiling Point: 929.3ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 312ºC

(E)-methyl isoeugenol

cis-Methylisoeugenol (compound 10) can be isolated from the MeOH extract of R. fasciculatum[1].

  • CAS Number: 6380-24-1
  • MF: C11H14O2
  • MW: 178.23
  • Catalog: Others
  • Density: 1.0±0.1 g/cm3
  • Boiling Point: 271.1±20.0 °C at 760 mmHg
  • Melting Point: 70°C
  • Flash Point: 104.5±21.3 °C

LL 37

LL-37, Human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity[1]. LL-37, Human could help protect the cornea from infection and modulates wound healing[2].

  • CAS Number: 154947-66-7
  • MF: C205H340N60O53
  • MW:
  • Catalog: Infection
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

(±)-2-hydroxybutyric acid

2-Hydroxybutyric acid (α-Hydroxybutyric acid ) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite[1].

  • CAS Number: 600-15-7
  • MF: C4H8O3
  • MW: 104.104
  • Catalog: Others
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 238.3±13.0 °C at 760 mmHg
  • Melting Point: 44ºC
  • Flash Point: 112.2±16.3 °C

Substance P (2-11)

Substance P (2-11) is a substance P (SP) fragment peptide. Substance P (2-11) has contracting activities on guinea pig ileum. Substance P (2-11) inhibits the permeation of 3H SP in BBMEC monolayers[1][2].

  • CAS Number: 53749-61-4
  • MF: C57H86N14O12S
  • MW: 1191.44000
  • Catalog: Neurological Disease
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

(4S)-4-amino-4-[[(1S)-4-amino-1-carboxy-butyl]carbamoyl]butanoic acid

γ-Glutamylornithine is the urine excreta of patients with HHH syndrome (hyperuricemia, hyperaminemia, and hypercitrullinuria) and rotary atrophy associated with hyperuricemia. Increased levels of endogenous ornithine increase levels of γ-Glutamylornithine in the urine[1].

  • CAS Number: 56523-61-6
  • MF: C10H19N3O5
  • MW: 261.275
  • Catalog: Others
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 613.7±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 324.9±31.5 °C

16-Azidohexadecanoic acid

16-Azidohexadecanoic acid, a synthetic fatty acid, can be used as a modification marker for nucleotides and a molecular probe for fatty acid metabolism[1][2].

  • CAS Number: 112668-54-9
  • MF: C16H31N3O2
  • MW: 297.43600
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Cipropride S enantiomer

Cipropride (S enantiomer) is the S enantiomer of cipropride; cipropride is an antiemetic drug.

  • CAS Number: 66183-70-8
  • MF: C17H25N3O4S
  • MW: 367.46
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

1-Hexanol

1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties[1]. 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism[2].

  • CAS Number: 111-27-3
  • MF: C6H14O
  • MW: 102.175
  • Catalog: Others
  • Density: 0.8±0.1 g/cm3
  • Boiling Point: 158.2±3.0 °C at 760 mmHg
  • Melting Point: −52 °C(lit.)
  • Flash Point: 60.0±0.0 °C

Tectorigenin 7-O-xylosylglucoside

Tectorigenin 7-​O-​Xylosyl Glucoside is a glycosidic isoflavone isolated from Pueraria thomsonii flower[1].

  • CAS Number: 231288-19-0
  • MF: C27H30O15
  • MW: 594.518
  • Catalog: Others
  • Density: 1.7±0.1 g/cm3
  • Boiling Point: 929.9±65.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 308.9±27.8 °C

Angiogenesis inhibitor 4

Angiogenesis inhibitor 4 is a potent angiogenesis inhibitor. Angiogenesis inhibitor 4 can be used in research of cancer[1].

  • CAS Number: 417719-77-8
  • MF: C27H30ClN5O5
  • MW: 540.01
  • Catalog: Cancer
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Fulvotomentoside B

Fulvotomentoside B is a saponin isolated from Lactobacillus flavus. Fulvotomentoside compounds can significantly reduce serum glutamate pyruvate transaminase (SGPT) and triacylglycerol (GT) levels in mice poisoned by CCl4, d-galactosamine (d-gal) and acetaminophen, and significantly alleviate liver pathology. damage[1].

  • CAS Number: 1021184-77-9
  • MF: C57H92O25
  • MW: 1177.33
  • Catalog: Metabolic Disease
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

(S)-3,6-DIAMINO-6-OXOHEXANOIC ACID HYDROCHLORIDE

L-β-Homoglutamine hydrochloride is a glutamine derivative[1].

  • CAS Number: 336182-05-9
  • MF: C6H13ClN2O3
  • MW: 196.63200
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

erythro-Guaiacylglycerol beta-coniferyl ether

Erythro-Guaiacylglycerol beta-coniferyl ether (compound 22) can be isolated from the stems and leaves of mung beans. Erythro-Guaiacylglycerol beta-coniferyl ether inhibits α-Glycosidase activity with EC50 value of 18.71 μM[1].

  • CAS Number: 890317-92-7
  • MF: C20H24O7
  • MW: 376.40
  • Catalog: Others
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 643.2±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 342.8±31.5 °C

α,β-Methyleneadenosine 5'-triphosphate(sodium salt)

α,β-Methylene ATP trisodium, a phosphonic analog of ATP, is a P2X3 and P2X7 receptor ligand[1].

  • CAS Number: 1343364-54-4
  • MF: C11H15N5Na3O12P3
  • MW: 571.15
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

(2H14)Benzo[rst]pentaphene

Dibenzo(a,i)pyrene-d14 is the deuterium labeled Dibenzo(a,i)pyrene[1].

  • CAS Number: 158776-07-9
  • MF: C24D14
  • MW: 316.454
  • Catalog: Others
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 552.3±17.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 282.0±15.1 °C