2364326-23-6
2364326-23-6 structure
- Name: SPH5030
- Chemical Name: SPH5030
- CAS Number: 2364326-23-6
- Molecular Formula: C31H31FN8O3
- Molecular Weight: 582.61
- Catalog: Research Areas Cancer
- Create Date: 2022-07-02 18:19:53
- Modify Date: 2025-08-25 12:17:28
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SPH5030 is a selective, potent, and irreversible HER2 mutants inhibitor with IC50 of <1 nM against HER2 D769H, D769Y, V777L and R896C mutants.SPH5030 exhibits high relative HER2 selectivity compared with neratinib and pyrotinib.SPH5030 shows significant in vivo antitumor efficacy in xenograft mouse models, especially in a HER2 mutation A775_G776insYVMA xenograft mouse mode.
| Name | SPH5030 |
|---|
| Description | SPH5030 is a selective, potent, and irreversible HER2 mutants inhibitor with IC50 of <1 nM against HER2 D769H, D769Y, V777L and R896C mutants.SPH5030 exhibits high relative HER2 selectivity compared with neratinib and pyrotinib.SPH5030 shows significant in vivo antitumor efficacy in xenograft mouse models, especially in a HER2 mutation A775_G776insYVMA xenograft mouse mode. |
|---|---|
| References | 1. Di Li, et al. Journal of Medicinal Chemistry March 23, 2022. |
| Molecular Formula | C31H31FN8O3 |
|---|---|
| Molecular Weight | 582.61 |