SPH5030
Modify Date: 2025-08-25 12:17:28
SPH5030 structure
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Common Name | SPH5030 | ||
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| CAS Number | 2364326-23-6 | Molecular Weight | 582.61 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C31H31FN8O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SPH5030SPH5030 is a selective, potent, and irreversible HER2 mutants inhibitor with IC50 of <1 nM against HER2 D769H, D769Y, V777L and R896C mutants.SPH5030 exhibits high relative HER2 selectivity compared with neratinib and pyrotinib.SPH5030 shows significant in vivo antitumor efficacy in xenograft mouse models, especially in a HER2 mutation A775_G776insYVMA xenograft mouse mode. |
| Name | SPH5030 |
|---|
| Description | SPH5030 is a selective, potent, and irreversible HER2 mutants inhibitor with IC50 of <1 nM against HER2 D769H, D769Y, V777L and R896C mutants.SPH5030 exhibits high relative HER2 selectivity compared with neratinib and pyrotinib.SPH5030 shows significant in vivo antitumor efficacy in xenograft mouse models, especially in a HER2 mutation A775_G776insYVMA xenograft mouse mode. |
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| References | 1. Di Li, et al. Journal of Medicinal Chemistry March 23, 2022. |
| Molecular Formula | C31H31FN8O3 |
|---|---|
| Molecular Weight | 582.61 |
| InChIKey | HTAMCULFUCGZAM-FKYOTISTSA-N |
| SMILES | CCOc1cc2ncnc(Nc3ccc(Oc4ccn5ncnc5c4)c(C)c3)c2cc1NC(=O)C(F)=CC1CCCN1C |