SPH5030
Names
[ CAS No. ]:
2364326-23-6
[ Name ]:
SPH5030
Biological Activity
[Description]:
SPH5030 is a selective, potent, and irreversible HER2 mutants inhibitor with IC50 of <1 nM against HER2 D769H, D769Y, V777L and R896C mutants.SPH5030 exhibits high relative HER2 selectivity compared with neratinib and pyrotinib.SPH5030 shows significant in vivo antitumor efficacy in xenograft mouse models, especially in a HER2 mutation A775_G776insYVMA xenograft mouse mode.
[References]
1. Di Li, et al. Journal of Medicinal Chemistry March 23, 2022.
Chemical & Physical Properties
[ Molecular Formula ]:
C31H31FN8O3
[ Molecular Weight ]:
582.61
Related Compounds
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