132-22-9

132-22-9 structure

Name: Chlorpheniramine
Chemical Name: chlorphenamine
CAS Number: 132-22-9
Molecular Formula: C₁₆H₁₉ClN₂
Molecular Weight: 274.78800
Catalog: Research Areas Inflammation/Immunology
Create Date: 2016-11-14 01:02:12
Modify Date: 2025-08-20 11:25:13
Chlorpheniramine is a H1 antihistamines commonly used in allergic diseases[1]. [2]. .

Name	chlorphenamine
Synonyms	(S)-[3-(4-chloro-phenyl)-3-[2]pyridyl-propyl]-dimethyl-amine D-Chlorpheniramine Isomerine Phendextro Dexclorfeniramina Polaramin Chlor-Trimeton Fortamine (+)-Chlorpheniramine DEXCHLORPHENIRAMINE [3H]-Chlorpheniramine chloropheniramine 3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine Destral (S)-[3-(4-Chlor-phenyl)-3-[2]pyridyl-propyl]-dimethyl-amin Trenelone

Description	Chlorpheniramine is a H1 antihistamines commonly used in allergic diseases[1]. [2]. .
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	IC50: 43μM in BV2 microglial cells
In Vitro	Chlorpheniramine has an inhibitory effects with an value of IC50 is 43μM on proton currents in BV2 microglial cells[1]. . Cell Viability Assay Cell Line: Murine microglial BV2 cells[1]. Concentration: 100 μM Incubation Time: 5 min Result: Inhibited proton currents with moderate potency.
In Vivo	Chloropheniramine (50, 100 and 200 μg/kg; IM; 3 times, at intervals of 1 week) enhances white blood cells in the peripheral blood[2]. . Animal Model: Sprague-Dawley (SD) rats[2]. Dosage: 50, 100 and 200 μg/kg Administration: Chlorpheniramine (50, 100 and 200 μg/kg; IM; 3 times, at intervals of 1 week) Result: Enhanced white blood cells in the peripheral blood, mostly due to the increases of B cells and monocytes, but not T cells and NK cells.
References	[1]. Jiwon Kim, etal. Inhibitory effects of antihistamines, diphenhydramine and chlorpheniramine, on proton currents in BV2 microglial cells. Eur J Pharmacol. 2017 Mar 5;798:122-128. [2]. Kyung-Jin Jung, etal. Enhancement of B cell and monocyte populations in rats exposed to chlorpheniramine. Arch Pharm Res. 2012 Dec;35(12):2183-9.