Top Suppliers:I want be here
Related CAS#:
112945-52-5 1327-36-2
308076-54-2 66813-85-2
69012-64-2 14464-46-1
66369-14-0 54088-50-5
126850-14-4 438582-69-5

112945-52-5

112945-52-5 structure
112945-52-5 structure
  • Name: Fumed silica
  • Chemical Name: Silica, fumed
  • CAS Number: 112945-52-5
  • Molecular Formula: O2Si
  • Molecular Weight: 60.08430
  • Catalog: Inorganic chemical industry Inorganic acid
  • Create Date: 2018-02-06 08:00:00
  • Modify Date: 2024-01-02 18:58:35
  • Amorphous silica can be used as an excipient, such as viscosifier, suspending agent, tablet disintegrating agent, adsorbent dispersing agent as liquid in powders. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1].
Name Silica, fumed
Synonyms Silica,Silicic anhydride,Silicon dioxide amorphous
MFCD00221516
Silicon dioxide
Silica,fumed
Fumed silica
Description Amorphous silica can be used as an excipient, such as viscosifier, suspending agent, tablet disintegrating agent, adsorbent dispersing agent as liquid in powders. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1].
Related Catalog
References

[1]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.  

Density 2.3 lb/cu.ft at 25 °C (bulk density)(lit.)
Boiling Point 2230ºC
Melting Point >1600°C
Molecular Formula O2Si
Molecular Weight 60.08430
Exact Mass 59.96680
PSA 34.14000
Appearance powder
Index of Refraction n20/D 1.46(lit.)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VV7310000
CHEMICAL NAME :
Silica, amorphous fumed
CAS REGISTRY NUMBER :
112945-52-5
LAST UPDATED :
199710
DATA ITEMS CITED :
18
MOLECULAR FORMULA :
O2-Si
MOLECULAR WEIGHT :
60.09
WISWESSER LINE NOTATION :
SI O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intratracheal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
154 mg/m3/6H/4W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases Biochemical - Metabolism (Intermediary) - other proteins
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
50 mg/m3/6H/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors
TYPE OF TEST :
Unscheduled DNA synthesis

MUTATION DATA

TYPE OF TEST :
Body fluid assay
TEST SYSTEM :
Rodent - rat Lung
DOSE/DURATION :
120 mg/kg
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 41,61,1986 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 42,39,1987 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 42,39,1987 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 68,41,1997 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 68,41,1997 TOXICOLOGY REVIEW NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: CONF-691001 TOXICOLOGY REVIEW ECRVE8 Environmental Carcinogenesis Reviews. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.3- 1985- Volume(issue)/page/year: 6,197,1988 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-dust in air:TWA 20 mppcf DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,33,1973
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Risk Phrases R37
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS VV7310000

Chemsrc provides CAS#:112945-52-5 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 112945-52-5 | Chemsrc address: https://www.chemsrc.com/en/baike/391432.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved