2,3,5,6-Tetrachloroaniline-d3 is the deuterium labeled 2,3,5,6-Tetrachloroaniline[1].
Human enteropeptidase-IN-1 (compound 6b) is a highly potent, orally active and low systemic exposure enteropeptidase inhibitor. Human enteropeptidase-IN-1 boosts the increase in fecal protein output, and exhibits potent body weight loss in diet-induced obese (DIO) rat model. Human enteropeptidase-IN-1 can be used for anti-obesity research[1].
Ethyl linoleate-13C18 (Linoleic Acid-13C18 ethyl ester) is the 13C labeled Ethyl linoleate. Ethyl linoleate inhibit the development of atherosclerotic lesions and the expression of inflammatory mediators[1].
H-Leu-Asp-OH is a biologically active peptide.
AP-C4 is an inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 5.2. AP-C3 does not inhibit cGKII-dependent anion secretion[1].
N,N-Dimethylglycine hydrochloride is a Glycine (HY-Y0966) derivative[1].
Monomethyl auristatin E intermediate-13 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].
Bazedoxifene acetate is a third generation selective estrogen receptor modulator (SERM) with IC50s of 26 and 99 nM for ERα and ERβ, respectively.
11-Hydroxyhumantenine is an alkaloid compound isolated from the EtOH extract of the stems of Gelsemium elegans[1].
Araliadiol is a polyacetylenic compound isolated from the leaves of Aralia cordata Thunb. Araliadiol inhibits MCF-7 cells growth with an IC50 value of 6.41 µg/mL[1].
6-Chloro-L-tryptophan is a Tryptophan derivative. 6-Chloro-L-tryptophan can be used as a substrate for KtzQ[1].
Substance P, [Met-OMet11] is a selective SP-P agonist. Substance P, [Met-OMet11] also is an active peptide. Substance P, [Met-OMet11] can be used for various biochemical studies[1][2].
Tri-p-tolylamine-15N is the deuterium labeled Tri-p-tolylamine[1].
Duoperone is a neuroleptic agent and also a antiemetic agent in animal models.
K114, a fluorescent Congo Red analogue, binds tightly to amyloid fibrils with an EC50 of 20-30 nM[1].
4-(Dimethylamino)phenol increases the extracellular lactate dehydrogenase (LDH) without markedly affecting gluconeogenesis. 4-(Dimethylamino)phenol cannot decreases the ATP content until the membrane becomes permeable to LDH[1].
NADPH tetra cyclohexanamine is a ubiquitous cofactor and biological reducing agent.
Angelol A is a coumarin isolated from the roots of Angelica pubescens f. biserrata, which is passive diffusion as the dominating process in Caco-2 cell monolayer model[1].
MeOSuc-Arg-Pro-Tyr-pNA is a biological active peptide. (chymotrypsin substrate)
Sorbitan monooctadecanoate is a hydrophobic nonionic surfactant. Sorbitan monooctadecanoate can be used as an excipient, such as emulsifiers, nonionic surfactants, solubilizers, wetting and dispersing/suspending agents. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].
5-O-Demethyl-28-hydroxy-Avermectin A1a is a degradation product of Avermectin B1a (HY-15308).
4-Fluorobenzoic-2,3,5,6-d4 acid is the deuterium labeled 4-Fluorobenzoic-2,3,5,6-d4 acid[1].
3-Pyridinecarboxaldehyde-d4 is the deuterium labeled 3-Pyridinecarboxaldehyde[1].
Z-dehydro-Ala-OH is an alanine derivative[1].
Norelgestromin is a metabolite of Norgestimate, which is a progestin or synthetic progestogen.
pTH-Related Protein (1-34) amide (human, mouse, rat) (Human PTHrP-(1-34)NH2) is a N-terminal fragments of PTHrP. pTH-Related Protein (1-34) amide (human, mouse, rat) induces hypercalcemia, and can be used for research of humoral hypercalcaemia of malignancy[1].
Carbutamide (BZ-55) is an orally active and first-generation sulfonylurea with hypoglycemic activity[1].
TM-25659 is a TAZ modulator. Anti-osteoporotic and anti-obesity activities[1].
Bazedoxifene-d4 (acetate) is the deuterium labeled Bazedoxifene[1]. Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer[2][3].
Siaresinolic acid 28-O-β-D-glucopyranosyl ester possesses anti-tumor and antidiabetic effect activity[1][2].