Span 60

Modify Date: 2024-01-02 17:08:53

Span 60 Structure
Span 60 structure
 Common Name Span 60
CAS Number 1338-41-6 Molecular Weight 430.618
Density 1.1±0.1 g/cm3 Boiling Point 579.0±45.0 °C at 760 mmHg
Molecular Formula C24H46O6 Melting Point 54-57 °C(lit.)
MSDS Chinese USA Flash Point 185.3±22.2 °C

 Use of Span 60


Sorbitan monooctadecanoate is a hydrophobic nonionic surfactant. Sorbitan monooctadecanoate can be used as an excipient, such as emulsifiers, nonionic surfactants, solubilizers, wetting and dispersing/suspending agents. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].

 Names

Name Span 60
Synonym More Synonyms

 Span 60 Biological Activity

Description Sorbitan monooctadecanoate is a hydrophobic nonionic surfactant. Sorbitan monooctadecanoate can be used as an excipient, such as emulsifiers, nonionic surfactants, solubilizers, wetting and dispersing/suspending agents. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].
Related Catalog
References

[1]. Murdan S, et al. Novel sorbitan monostearate organogels[J]. Journal of pharmaceutical sciences, 1999, 88(6): 608-614.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.  

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 579.0±45.0 °C at 760 mmHg
Melting Point 54-57 °C(lit.)
Molecular Formula C24H46O6
Molecular Weight 430.618
Flash Point 185.3±22.2 °C
Exact Mass 430.329437
PSA 96.22000
LogP 7.13
Vapour Pressure 0.0±3.6 mmHg at 25°C
Index of Refraction 1.497
Stability Stable. Combustible. Incompatible with strong oxidizing agents.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WG2933500
CHEMICAL NAME :
Sorbitan, monostearate
CAS REGISTRY NUMBER :
1338-41-6
LAST UPDATED :
199710
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C24-H46-O6
MOLECULAR WEIGHT :
430.70

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(3),65,1985 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
31 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ. Volume(issue)/page/year: 21,348,1956 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2730 gm/kg/2Y-C
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,315,1959 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
635 gm/kg
SEX/DURATION :
multigenerations
TOXIC EFFECTS :
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
REFERENCE :
JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 60,489,1956
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1270 gm/kg
SEX/DURATION :
female 84 day(s) pre-mating - 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
REFERENCE :
JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 60,489,1956 *** REVIEWS *** TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(3),65,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81999 No. of Facilities: 693 (estimated) No. of Industries: 15 No. of Occupations: 25 No. of Employees: 14579 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81999 No. of Facilities: 6199 (estimated) No. of Industries: 63 No. of Occupations: 72 No. of Employees: 189741 (estimated) No. of Female Employees: 71370 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS WG2933500
HS Code 34021300

 Customs

HS Code 2932190090
Summary 2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

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 Synonyms

EINECS 215-664-9
Drewsorb 60
1,4-anhydro-6-O-octadecanoyl-D-glucitol
D-Glucitol, 1,4-anhydro-5-O-(1-oxooctadecyl)-
1,4-Anhydro-D-glucitol 6-octadecanoate
SPAN(R) 60
Arlacel 60
SPAN(TM) 60
Barchlor 16S
Durtan 60
Glycomul S
1,4-Anhydro-5-O-stearoyl-D-glucitol
D-Glucitol, 1,4-anhydro-, 6-octadecanoate
1,4-Anhydro-D-glucitol, 6-octadecanoate
SPAN NO 60
Span(rg 60
Lonzest(R) SMS
Emsorb 2505
UNII:NVZ4I0H58X
1,4-Anhydro-6-O-stearoyl-D-glucitol
(Sorbitan Monostearate)
Sorbitan stearate Sorbitane monostearate
D-Glucitol, 1,4-anhydro-6-O-(1-oxooctadecyl)-
FEMA 3028
Sorbitan Monostearate
MFCD00005366
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Chemsrc provides Span 60(CAS#:1338-41-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Span 60 are included as well.>> amp version: Span 60

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