Span 60
Span 60 structure
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Common Name | Span 60 | ||
|---|---|---|---|---|
| CAS Number | 1338-41-6 | Molecular Weight | 430.618 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 579.0±45.0 °C at 760 mmHg | |
| Molecular Formula | C24H46O6 | Melting Point | 54-57 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 185.3±22.2 °C | |
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Trypanocidal activity of free and nanoencapsulated curcumin on Trypanosoma evansi.
Parasitology 142(3) , 439-48, (2015) This study aimed to evaluate in vitro and in vivo trypanocidal activity of free and nanoencapsulated curcumin against Trypanosoma evansi. In vitro efficacy of free curcumin (CURC) and curcumin-loaded in lipid-core nanocapsules (C-LNCs) was evaluated to verify... |
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New topical photodynamic therapy for treatment of hidradenitis suppurativa using methylene blue niosomal gel: a single-blind, randomized, comparative study.
Clin. Exp. Dermatol. 40(2) , 116-22, (2015) Hidradenitis suppurativa (HS), is a chronic, recurrent dermatosis affecting skin that contains apocrine glands. Photodynamic therapy using aminolaevulinic acid (ALA) activated by intense pulsed light (IPL) have shown variable success rates, with some adverse ... |
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Prednisolone-loaded nanocapsules as ocular drug delivery system: development, in vitro drug release and eye toxicity.
J. Microencapsul. 31(6) , 519-28, (2014) To develop non-toxic aqueous ocular drug delivery systems containing prednisolone by means of its nanoencapsulation.Nanocapsules were prepared by interfacial deposition of preformed polymer [poly(ε-caprolactone) or Eudragit® RS100]. Particle size distribution... |
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Caenorhabditis elegans as an alternative in vivo model to determine oral uptake, nanotoxicity, and efficacy of melatonin-loaded lipid-core nanocapsules on paraquat damage.
Int. J. Nanomedicine 10 , 5093-106, (2015) Caenorhabditis elegans is an alternative in vivo model that is being successfully used to assess the pharmacological and toxic effects of drugs. The exponential growth of nanotechnology requires the use of alternative in vivo models to assess the toxic effect... |
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A novel approach to arthritis treatment based on resveratrol and curcumin co-encapsulated in lipid-core nanocapsules: In vivo studies.
Eur. J. Pharm. Sci. 78 , 163-70, (2015) Resveratrol and curcumin are two natural polyphenols extensively used due to their remarkable anti-inflammatory activity. The present work presents an inedited study of the in vivo antioedematogenic activity of these polyphenols co-encapsulated in lipid-core ... |
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Development of artemether-loaded nanostructured lipid carrier (NLC) formulation for topical application.
Int. J. Pharm. 477(1-2) , 208-17, (2014) NLC topical formulation as an alternative to oral and parenteral (IM) delivery of artemether (ART), a poorly water-soluble drug was designed. A Phospholipon 85G-modified Gelucire 43/01 based NLC formulation containing 75% Transcutol was chosen from DSC studie... |
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Nano-transfersomal ciprofloxacin loaded vesicles for non-invasive trans-tympanic ototopical delivery: in-vitro optimization, ex-vivo permeation studies, and in-vivo assessment.
Int. J. Pharm. 472(1-2) , 304-14, (2014) Ciprofloxacin is a synthetic fluoroquinolone antibiotic that has been used for systemic treatment of otitis media in adults. It was approved for topical treatment of otorrhea in children with tympanostomy tubes. The aim of this work was to enhance the local n... |
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Proniosomal oral tablets for controlled delivery and enhanced pharmacokinetic properties of acemetacin.
AAPS PharmSciTech 16(2) , 375-83, (2015) Free-flowing proniosomal powders of acemetacin (AC) were prepared using the slurry method and maltodextrin as carrier. Positively charged proniosomes composed of 70:20:10 of Span 60/cholesterol (Chol)/stearylamine (SA), respectively, were successively compres... |
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Fatty alcohols or fatty acids as niosomal hybrid carrier: effect on vesicle size, encapsulation efficiency and in vitro dye release.
Colloids Surf. B Biointerfaces 58(1) , 68-71, (2007) Niosomal hybrid mixtures are prepared with bilayer stabilizer cholesterol from non-ionic surfactants span 20 (HLB value 8.6), span 60 (HLB 4.7) and span 85 (HLB 1.8) in presence of dicetyl phosphate (DCP) where fatty acids or fatty alcohols (C14, C16 and C18)... |
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The preparation of pellets containing non-ionic surfactants by extrusion/spheronization.
Int. J. Pharm. 361(1-2) , 33-40, (2008) The aim of the study was to investigate the possibility of incorporating non-ionic surfactants into pellets produced from microcrystalline cellulose by the process of extrusion/spheronization and the properties of the pellets. A hydrophilic surfactant, polyso... |