Span 40

Modify Date: 2024-01-02 10:58:25

Span 40 Structure
Span 40 structure
 Common Name Span 40
CAS Number 26266-57-9 Molecular Weight 402.565
Density 1.1±0.1 g/cm3 Boiling Point 558.2±45.0 °C at 760 mmHg
Molecular Formula C22H42O6 Melting Point 46-47 °C(lit.)
MSDS USA Flash Point 182.4±22.2 °C

 Use of Span 40


Sorbitan monopalmitate is used for niosomes particle preparation. Sorbitan monopalmitate can be used as an excipient, such as nonionic surfactants, emulsifiers. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].

 Names

Name Sorbitan monopalmitate
Synonym More Synonyms

 Span 40 Biological Activity

Description Sorbitan monopalmitate is used for niosomes particle preparation. Sorbitan monopalmitate can be used as an excipient, such as nonionic surfactants, emulsifiers. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].
Related Catalog
References

[1]. Essa E A. Effect of formulation and processing variables on the particle size of sorbitan monopalmitate niosomes[J]. Asian Journal of Pharmaceutics (AJP), 2010, 4(4).

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.  

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 558.2±45.0 °C at 760 mmHg
Melting Point 46-47 °C(lit.)
Molecular Formula C22H42O6
Molecular Weight 402.565
Flash Point 182.4±22.2 °C
Exact Mass 402.298126
PSA 96.22000
LogP 6.59
Vapour Pressure 0.0±3.4 mmHg at 25°C
Index of Refraction 1.499

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WG2932900
CHEMICAL NAME :
Sorbitan, monopalmitate
CAS REGISTRY NUMBER :
26266-57-9
LAST UPDATED :
199701
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C22-H42-O6
MOLECULAR WEIGHT :
402.64

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(3),65,1985
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(3),65,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1485 No. of Facilities: 619 (estimated) No. of Industries: 16 No. of Occupations: 23 No. of Employees: 25049 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1485 No. of Facilities: 397 (estimated) No. of Industries: 12 No. of Occupations: 21 No. of Employees: 22189 (estimated) No. of Female Employees: 13283 (estimated)

 Safety Information

Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS WG2932900
HS Code 2932190090

 Customs

HS Code 2932190090
Summary 2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

 Articles18

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Chemical compositions and biological activities of the essential oils of Beilschmiedia madang Blume (Lauraceae).

Arch. Pharm. Res. 38(4) , 485-93, (2015)

The present study aimed to examine the chemical compositions of the essential oils of Beilschmiedia madang and their antioxidant, antibacterial, antifungal, anticholinesterase and anti-tyrosinase acti...
Paclitaxel-loaded niosomes for intravenous administration: pharmacokinetics and tissue distribution in rats.

Turk. J. Med. Sci. 45 , 1403-12, (2016)

The purpose of this study was to investigate and compare the pharmacokinetic behavior and tissue distribution of paclitaxel, delivered as commercial preparation Taxol or through Span 40 niosomes, afte...
Conversion of polar and non-polar algae oil lipids to fatty acid methyl esters with solid acid catalysts--A model compound study.

Bioresour. Technol. 191 , 300-5, (2015)

Bio-based fuels are becoming more and more important due to the depleting fossil resources. The production of biodiesel from algae oil is challenging compared to terrestrial vegetable oils, as algae o...

 Synonyms

1,4-Anhydro-6-O-palmitoyl-D-glucitol
Sorbitan, monohexadecanoate
montane40
SPAN NO 40
emsorb2510
Sorbitan Monopalmitate
sorgen70
EINECS 247-568-8
liposorbp
(Sorbitan MonopalMitate)
1,4-anhydro-6-O-hexadecanoyl-D-glucitol
1,4-Anhydro-D-glucitol, 6-hexadecanoate
D-Glucitol, 1,4-anhydro-, 6-hexadecanoate
glycomulp
MFCD00080946
SPAN(R) 40
ARLACEL 40
D-Glucitol, 1,4-anhydro-6-O-(1-oxohexadecyl)-
crill2
Span 40
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Chemsrc provides Span 40(CAS#:26266-57-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Span 40 are included as well.>> amp version: Span 40

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