865285-47-8
865285-47-8 structure
- Name: KKL-40
- Chemical Name: N-[5-(4-Fluorophenyl)-1,3,4-oxadiazol-2-yl]-3-(trifluoromethyl)benzamide
- CAS Number: 865285-47-8
- Molecular Formula: C16H9F4N3O2
- Molecular Weight: 351.255
- Create Date: 2020-01-11 09:13:52
- Modify Date: 2024-01-03 14:47:31
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A small-molecule inhibitor of bacterial ribosome rescue that exhibits broad-spectrum antimicrobial activity against bacteria grown in liquid culture; exhibited exceptional antimicrobial activity against both attenuated (LVS) and fully virulent strains of F. tularensis (Schu S4) in vitro with MIC of 0.12 and 0.44 ug/mL, respectively; arrests intracellular growth of F. tularensis during all stages of infection, does not affect macrophage viability or function.
| Name | N-[5-(4-Fluorophenyl)-1,3,4-oxadiazol-2-yl]-3-(trifluoromethyl)benzamide |
|---|---|
| Synonyms |
N-[5-(4-Fluorophenyl)-1,3,4-oxadiazol-2-yl]-3-(trifluoromethyl)benzamide
Benzamide, N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-3-(trifluoromethyl)- |
| Description | A small-molecule inhibitor of bacterial ribosome rescue that exhibits broad-spectrum antimicrobial activity against bacteria grown in liquid culture; exhibited exceptional antimicrobial activity against both attenuated (LVS) and fully virulent strains of F. tularensis (Schu S4) in vitro with MIC of 0.12 and 0.44 ug/mL, respectively; arrests intracellular growth of F. tularensis during all stages of infection, does not affect macrophage viability or function. |
|---|---|
| References | References 1. Goralski TD, et al. Antimicrob Agents Chemother. 2016 May 23;60(6):3276-82. View Related Products by Target Bacterial |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C16H9F4N3O2 |
| Molecular Weight | 351.255 |
| Exact Mass | 351.063080 |
| LogP | 4.43 |
| Index of Refraction | 1.570 |