Span 40

Names

[ Name ]:
Span 40

[Synonym ]:
1,4-Anhydro-6-O-palmitoyl-D-glucitol
Sorbitan, monohexadecanoate
montane40
SPAN NO 40
emsorb2510
Sorbitan Monopalmitate
sorgen70
EINECS 247-568-8
liposorbp
(Sorbitan MonopalMitate)
1,4-anhydro-6-O-hexadecanoyl-D-glucitol
1,4-Anhydro-D-glucitol, 6-hexadecanoate
D-Glucitol, 1,4-anhydro-, 6-hexadecanoate
glycomulp
MFCD00080946
SPAN(R) 40
ARLACEL 40
D-Glucitol, 1,4-anhydro-6-O-(1-oxohexadecyl)-
crill2
Span 40

Biological Activity

[Description]:

Sorbitan monopalmitate is used for niosomes particle preparation. Sorbitan monopalmitate can be used as an excipient, such as nonionic surfactants, emulsifiers. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Essa E A. Effect of formulation and processing variables on the particle size of sorbitan monopalmitate niosomes[J]. Asian Journal of Pharmaceutics (AJP), 2010, 4(4).

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
558.2±45.0 °C at 760 mmHg

[ Melting Point ]:
46-47 °C(lit.)

[ Molecular Formula ]:
C₂₂H₄₂O₆

[ Molecular Weight ]:
402.565

[ Flash Point ]:
182.4±22.2 °C

[ Exact Mass ]:
402.298126

[ PSA ]:
96.22000

[ LogP ]:
6.59

[ Vapour Pressure ]:
0.0±3.4 mmHg at 25°C

[ Index of Refraction ]:
1.499

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WG2932900

CHEMICAL NAME :: Sorbitan, monopalmitate

CAS REGISTRY NUMBER :: 26266-57-9

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C22-H42-O6

MOLECULAR WEIGHT :: 402.64

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(3),65,1985

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(3),65,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1485 No. of Facilities: 619 (estimated) No. of Industries: 16 No. of Occupations: 23 No. of Employees: 25049 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1485 No. of Facilities: 397 (estimated) No. of Industries: 12 No. of Occupations: 21 No. of Employees: 22189 (estimated) No. of Female Employees: 13283 (estimated)

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
WG2932900

[ HS Code ]:
2932190090

Customs

[ HS Code ]: 2932190090

[ Summary ]:
2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Articles

Chemical compositions and biological activities of the essential oils of Beilschmiedia madang Blume (Lauraceae).

Arch. Pharm. Res. 38(4) , 485-93, (2015)

The present study aimed to examine the chemical compositions of the essential oils of Beilschmiedia madang and their antioxidant, antibacterial, antifungal, anticholinesterase and anti-tyrosinase acti...

Paclitaxel-loaded niosomes for intravenous administration: pharmacokinetics and tissue distribution in rats.

Turk. J. Med. Sci. 45 , 1403-12, (2016)

The purpose of this study was to investigate and compare the pharmacokinetic behavior and tissue distribution of paclitaxel, delivered as commercial preparation Taxol or through Span 40 niosomes, afte...

Conversion of polar and non-polar algae oil lipids to fatty acid methyl esters with solid acid catalysts--A model compound study.

Bioresour. Technol. 191 , 300-5, (2015)

Bio-based fuels are becoming more and more important due to the depleting fossil resources. The production of biodiesel from algae oil is challenging compared to terrestrial vegetable oils, as algae o...