Propargyl-PEG9-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Propargyl-PEG4-tetra-Ac-beta-D-glucose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Azido-PEG3-SS-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
HaloPROTAC 2, a chloroalkane-containing PROTAC, induces degradation of HaloTag fusion proteins.
S-acetyl-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Iodo-PEG4-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Azido-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Biotin-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Thalidomide-4-NH-PEG1-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-4-NH-PEG1-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-NH-PEG1-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
Tos-PEG8-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Fmoc-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
NU223612 is a potent PROTAC (PROTACs) that degrades indoleamine 2,3-dioxygenase 1 (IDO1) (Indoleamine 2,3-Dioxygenase (IDO)) with a Kd of 640 nM. NU223612 potently degrades the IDO1 protein through CRBN-mediated proteasomal degradation. NU223612 is bound to CRBN with an affinity of 290 nM. NU223612 can cross the blood-brain barrier (BBB)[1].
DNP-NH-PEG4-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Thalidomide-5-NH-PEG1-NH2 hydrochloride is a Thalidomide (HY-14658)-based cereblon ligand that recruits CRBN proteins. Thalidomide-5-NH-PEG1-NH2 hydrochloride can be connected to the target protein ligand through a linker to form a PROTAC molecule. For example, THAL-SNS-032 (HY-123937).
Ald-CH2-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Benzyl-PEG9-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Boc-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Azide-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTAC Linker 8 (Compound 15b) is a PROTAC linker can be used in the synthesis of a series of SNIPER(ER)s. SNIPER(ER)s contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. SNIPER(ER)s induce polyubiquitylation and proteasomal degradation of the target proteins in the cells[1].
Chloro-PEG5-chloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Novel degrader of HaloTag Fusion Proteins
DSPE-PEG2-mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Pomalidomide-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 22) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology[1].
BSJ-04-132 is a potent and selective Ribociclib-based CDK4 degrader (PROTAC), with IC50s of 50.6 nM and 30 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-04-132 does not induce CDK6 and IKZF1/3 degradation. BSJ-04-132 has anti-cancer activity[1].
N-(Azido-PEG3)-N-Boc-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
A VHL ligand for PROTAC.
Boc-NH-PEG3-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PAC comprises an antibody conjugated via a linker to a PROTAC. PAC extracts from patent WO2017201449A1, compound PAC1. PAC is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab).
N-(PEG2-C2-acid)-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Alkynyl Stearic Acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].