BSJ-04-132

Modify Date: 2024-01-14 20:20:09

BSJ-04-132 structure	Common Name	BSJ-04-132
	CAS Number	2349356-39-2	Molecular Weight	819.91
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₂H₄₉N₁₁O₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of BSJ-04-132

BSJ-04-132 is a potent and selective Ribociclib-based CDK4 degrader (PROTAC), with IC50s of 50.6 nM and 30 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-04-132 does not induce CDK6 and IKZF1/3 degradation. BSJ-04-132 has anti-cancer activity[1].

Name	BSJ-04-132

Description	BSJ-04-132 is a potent and selective Ribociclib-based CDK4 degrader (PROTAC), with IC50s of 50.6 nM and 30 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-04-132 does not induce CDK6 and IKZF1/3 degradation. BSJ-04-132 has anti-cancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Signaling Pathways >> PROTAC >> PROTAC
Target	CDK4/D1:50.6 nM (IC50) CDK6/D1:30 nM (IC50)
In Vitro	BSJ-04-132 (0.1-5 μM; for 4 hours) only resultes in degradation of CDK4 in WT cells, not CDK6 and IKZF1/3[1]. Western Blot Analysis[1] Cell Line: Wildtype (WT) or Crbn-/- Jurkat cells Concentration: 0.1, 0.5, 1, 5 μM Incubation Time: For 4 hours Result: Only resulted in degradation of CDK4 in WT cells, not CDK6 and IKZF1/3.
References	[1]. Baishan Jiang, et al. Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Angew Chem Int Ed Engl. 2019 May 6;58(19):6321-6326.

Molecular Formula	C₄₂H₄₉N₁₁O₇
Molecular Weight	819.91

Hazard Codes	Xi

DC Chemicals Limited
China
Product Name: BSJ-04-132
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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