Ro 04-6790
Ro 04-6790 structure
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Common Name | Ro 04-6790 | ||
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| CAS Number | 202466-68-0 | Molecular Weight | 308.359 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 595.8±60.0 °C at 760 mmHg | |
| Molecular Formula | C12H16N6O2S | Melting Point | N/A | |
| MSDS | USA | Flash Point | 314.1±32.9 °C | |
Use of Ro 04-6790Ro 04-6790 is a potent, competitive and selective 5-HT6 receptor antagonist with pKi values of 7.26, 7.35 for rat and human 5-HT6 receptors, respectively. Ro 04-6790 has no affinity at other receptors[1]. |
| Name | Ro 04-6790 dihydrochloride |
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| Synonym | More Synonyms |
| Description | Ro 04-6790 is a potent, competitive and selective 5-HT6 receptor antagonist with pKi values of 7.26, 7.35 for rat and human 5-HT6 receptors, respectively. Ro 04-6790 has no affinity at other receptors[1]. |
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| Related Catalog | |
| Target |
Rat 5-HT6 Receptor:7.26 (pKi) Human 5-HT6 Receptor:7.35 (pKi) |
| In Vitro | Ro 04-6790 has over 100 fold selective for the 5-HT6 receptor compared to other receptor binding sites (IC50>10 μM)[1]. |
| In Vivo | Ro 04-6790 (10 mg/kg, SC) produces a modest (50%) increase in ACh outflow in adult male Wistar rats of 250-300 g (this effect is not statistically different from the action of vehicle)[2]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 595.8±60.0 °C at 760 mmHg |
| Molecular Formula | C12H16N6O2S |
| Molecular Weight | 308.359 |
| Flash Point | 314.1±32.9 °C |
| Exact Mass | 308.105530 |
| PSA | 130.41000 |
| LogP | -0.52 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.700 |
| Hazard Codes | Xi |
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| RIDADR | NONH for all modes of transport |
| RTECS | DA9462500 |
| HS Code | 2935009090 |
| HS Code | 2935009090 |
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| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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Characterization of Ro 04-6790 and Ro 63-0563: potent and selective antagonists at human and rat 5-HT6 receptors.
Br. J. Pharmacol. 124 , 556-562, (1998) 1. This study describes the in vitro characterization of two potent and selective 5-HT6 receptor antagonists at the rat and human recombinant 5-HT6 receptor. 2. In binding assays with [3H]-LSD, 4-amin... |
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Investigation of stretching behaviour induced by the selective 5-HT6 receptor antagonist, Ro 04-6790, in rats.
Br. J. Pharmacol. 126 , 1537-1542, (1999) 1. The present study examined the effects of the selective 5-HT6 receptor antagonist 4-amino-N-(2, 6 bis-methylamino-pyrimidin-4-yl)-benzene sulphonamide (Ro 04-6790) on locomotor activity and uncondi... |
| 4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]benzenesulfonamide |
| 4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]benzenesulfonamide dihydrobromide |
| Benzenesulfonamide, 4-amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]- |
| 4-Amino-N-[2,6-bis(methylamino)pyrimidin-4-yl]benzenesulfonamide |
| Ro 04-6790 |
| 4-amino-N-(2,6-bis-methylaminopyrimidin-4-yl)benzenesulfonamide |