202466-68-0

202466-68-0 structure

Name: Ro 04-6790
Chemical Name: Ro 04-6790 dihydrochloride
CAS Number: 202466-68-0
Molecular Formula: C₁₂H₁₆N₆O₂S
Molecular Weight: 308.359
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-12-18 10:57:58
Modify Date: 2024-01-08 13:07:16
Ro 04-6790 is a potent, competitive and selective 5-HT6 receptor antagonist with pKi values of 7.26, 7.35 for rat and human 5-HT6 receptors, respectively. Ro 04-6790 has no affinity at other receptors[1].

Name	Ro 04-6790 dihydrochloride
Synonyms	4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]benzenesulfonamide 4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]benzenesulfonamide dihydrobromide Benzenesulfonamide, 4-amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]- 4-Amino-N-[2,6-bis(methylamino)pyrimidin-4-yl]benzenesulfonamide Ro 04-6790 4-amino-N-(2,6-bis-methylaminopyrimidin-4-yl)benzenesulfonamide

Description	Ro 04-6790 is a potent, competitive and selective 5-HT6 receptor antagonist with pKi values of 7.26, 7.35 for rat and human 5-HT6 receptors, respectively. Ro 04-6790 has no affinity at other receptors[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	Rat 5-HT6 Receptor:7.26 (pKi) Human 5-HT6 Receptor:7.35 (pKi)
In Vitro	Ro 04-6790 has over 100 fold selective for the 5-HT6 receptor compared to other receptor binding sites (IC50>10 μM)[1].
In Vivo	Ro 04-6790 (10 mg/kg, SC) produces a modest (50%) increase in ACh outflow in adult male Wistar rats of 250-300 g (this effect is not statistically different from the action of vehicle)[2].
References	[1]. A J Sleight, et al. Characterization of Ro 04-6790 and Ro 63-0563: potent and selective antagonists at human and rat 5-HT6 receptors. Br J Pharmacol. 1998 Jun;124(3):556-62. [2]. Sudabeh Shirazi-Southall, et al. Effects of typical and atypical antipsychotics and receptor selective compounds on acetylcholine efflux in the hippocampus of the rat. Neuropsychopharmacology. 2002 May;26(5):583-94.

Hazard Codes	Xi
RIDADR	NONH for all modes of transport
RTECS	DA9462500
HS Code	2935009090

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%