2349356-39-2

2349356-39-2 structure

Name: BSJ-04-132
Chemical Name: BSJ-04-132
CAS Number: 2349356-39-2
Molecular Formula: C₄₂H₄₉N₁₁O₇
Molecular Weight: 819.91
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2020-12-26 09:34:17
Modify Date: 2024-01-14 20:20:09
BSJ-04-132 is a potent and selective Ribociclib-based CDK4 degrader (PROTAC), with IC50s of 50.6 nM and 30 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-04-132 does not induce CDK6 and IKZF1/3 degradation. BSJ-04-132 has anti-cancer activity[1].

Name	BSJ-04-132

Description	BSJ-04-132 is a potent and selective Ribociclib-based CDK4 degrader (PROTAC), with IC50s of 50.6 nM and 30 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-04-132 does not induce CDK6 and IKZF1/3 degradation. BSJ-04-132 has anti-cancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Signaling Pathways >> PROTAC >> PROTAC
Target	CDK4/D1:50.6 nM (IC50) CDK6/D1:30 nM (IC50)
In Vitro	BSJ-04-132 (0.1-5 μM; for 4 hours) only resultes in degradation of CDK4 in WT cells, not CDK6 and IKZF1/3[1]. Western Blot Analysis[1] Cell Line: Wildtype (WT) or Crbn-/- Jurkat cells Concentration: 0.1, 0.5, 1, 5 μM Incubation Time: For 4 hours Result: Only resulted in degradation of CDK4 in WT cells, not CDK6 and IKZF1/3.
References	[1]. Baishan Jiang, et al. Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Angew Chem Int Ed Engl. 2019 May 6;58(19):6321-6326.

Molecular Formula	C₄₂H₄₉N₁₁O₇
Molecular Weight	819.91

Hazard Codes	Xi