Pomalidomide-amido-PEG3-C2-NH2

Modify Date: 2024-01-09 20:40:37

Pomalidomide-amido-PEG3-C2-NH2 structure	Common Name	Pomalidomide-amido-PEG3-C2-NH2
	CAS Number	2328070-52-4	Molecular Weight	476.48
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₈N₄O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Pomalidomide-amido-PEG3-C2-NH2

Pomalidomide-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 22) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology[1].

Name	Pomalidomide-amido-PEG3-C2-NH2

Description	Pomalidomide-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 22) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	Cereblon
In Vitro	Pomalidomide-amido-PEG3-C2-NH2 (Compound 5b) can be used to synthesize BI-3663. BI-3663 (cereblon-based) degrades focal adhesion tyrosine kinase (PTK2) with a median DC50 of 30 nM to >80% across a panel of 11 human hepatocellular carcinoma (HCC) cell lines[1].
References	[1]. Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520.

Molecular Formula	C₂₂H₂₈N₄O₈
Molecular Weight	476.48

Hazard Codes	Xi

DC Chemicals Limited
China
Product Name: Pomalidomide-amido-PEG3-C2-NH2
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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