Pomalidomide-PEG3-C2-NH2 hydrochloride

Modify Date: 2024-01-09 13:15:42

Pomalidomide-PEG3-C2-NH2 hydrochloride Structure
Pomalidomide-PEG3-C2-NH2 hydrochloride structure
 Common Name Pomalidomide-PEG3-C2-NH2 hydrochloride
CAS Number 2446474-09-3 Molecular Weight 484.93
Density N/A Boiling Point N/A
Molecular Formula C21H29ClN4O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Pomalidomide-PEG3-C2-NH2 hydrochloride


Pomalidomide-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 5) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology[1].

 Names

Name Pomalidomide-PEG3-C2-NH2 hydrochloride

 Pomalidomide-PEG3-C2-NH2 hydrochloride Biological Activity

Description Pomalidomide-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 5) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology[1].
Related Catalog
Target

Cereblon

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

 Chemical & Physical Properties

Molecular Formula C21H29ClN4O7
Molecular Weight 484.93

 Safety Information

Hazard Codes Xi
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