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34450-18-5

34450-18-5 structure
34450-18-5 structure

Name 17-Octadecynoic acid
Synonyms Octadec-17-ynoic acid
17-Octadecynoic acid
MFCD00077382
Description Alkynyl Stearic Acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl-Chain

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 0.9±0.1 g/cm3
Boiling Point 400.8±18.0 °C at 760 mmHg
Melting Point 142-148 °C(lit.)
Molecular Formula C18H32O2
Molecular Weight 280.445
Flash Point 194.7±15.9 °C
Exact Mass 280.240234
PSA 37.30000
LogP 6.86
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.470
Storage condition Store at RT
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2916190090
HS Code 2916190090
Summary 2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%
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