TBCA is a highly selective CK2 (casein kinase II) inhibitor with an IC50 of 110 nM and a Ki of 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases[1][2].
Desmethyl cariprazine is an active metabolite of Cariprazine[1]. Cariprazine, an antipsychotic drug candidate, exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM)[2].
N-Butylfluorescein is an alkyl-substituted fluorescein, can be used for synthesis of fluorogenic substrates for assaying phosphatidylinositol-specific phospholipase C[1].
CALP2 is a calmodulin (CaM) antagonist ( (Kd of 7.9 µM)) with high affinity for binding to the CaM EF-hand/Ca2+-binding site. CALP2 inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca2+ concentrations. CALP2 potently inhibits of adhesion and degranulation. CALP2 is also a strong activator of alveolar macrophages[1][2][3][4].
4-Chlorocatechol is a major degradation product of 4-chloro-2-aminophenol (4C2AP). 4-Chlorocatechol is also a substrate for catechol 1,2-dioxygenases and chlorocatechol dioxygenase[1][2].
p-APMSF is an irreversible inhibitor of serinase. p-APMSFhas substrate specificity for positively charged side chains of amino acids,lysine, or arginine. p-APMSF can be used to study the irreversible inhibitionof trypsin and thrombin [1].
ATR-IN-19 (Compound 15 R-configure) is an ATR inhibitor[1].
Furaltadone-d5 is the deuterium labeled DL-Cystathionine[1].
Saccharothrixin K, a glycosylated saccharothrixin, shows moderate inhibition against Helicobacter pylori G27, H. pylori 159, and Staphylococcus aureus ATCC25923 with MIC values of 16 μg/mL[1].
EZH2-IN-6 is an EZH2 inhibitor with enhanced antitumor activity.
Procumbide (compound 11) is a flavone glucoside. Procumbide can be isolated from Andrographis paniculata[1].
Azide-C2-Azide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
γ-Carboxy-D-glutamic acid is a glutamic acid derivative[1].
Erioside is found in Lasiosiphon eriocephalus[1].
S.pombe lumazine synthase-IN-1 is an inhibitor of lumazine synthases with Ki values of 243 μM and 9.6 μM for Schizosaccharomyces pombe and Mycobacterium tuberculosis lumazine synthases, respectively[1].
Dihydrowithaferin A (2, 3-dihydrowithaferin A) is a withanolide isolated from Withania somnifera. Dihydrowithaferin A is active against acetylcholinesterase (AChE)[1].
PPm, a derivative of penthiopyrad and hapten, is a representative member of the succinate dehydrogenase inhibitors group of fungicides[1].
Nav1.8-IN-2 (compound 35A) is a potent Nav1.8 inhibitor with an IC50 value of 0.4 nM. Nav1.8-IN-2 can be used for researching pain disorders, cough disorders, and acute and chronic itch disorders[1].
IDO-IN-2 is an IDO inhibitor extracted from patent WO/2015031295 A1, compound example 1, has IC50 values of 0.068 μM in HeLa cell and 0.16 μM in HEK293 cell.
N-Carbobenzoxy-L-proline tert-Butyl Ester is a proline derivative[1].
N-Methylacetamide-d3 is the deuterium labeled N-Methylacetamide[1].
BO3482 has Antimicrobial activity and can inhibit the growth of methicillin-resistant Staphylococci (MRS) with an MIC90 of 6.25 mg/mL.
16:1 SM (d18:1/16:1)-d9 is deuterium labeled 16:1 SM (d18:1/16:1).
7-O-Primverosylpseudobaptigenin is a natural product that can be isolated from the alcoholic extract of the roots of the Amur maackia[1].
2-Bromo-6-methoxynaphthalene is an active intermediate in the production of anti-inflammatory agents like Naproxen and Nabumetone by Heck reaction. 2-Bromo-6-methoxynaphthalene has potential anti-inflammatory properties and Tyrosine-protein inhibitor properties. 2-Bromo-6-methoxynaphthalene can be used for the research of cancer[1].
ARN14988 is a potent inhibitor of acid ceramidase (ACDase) (IC50=12.8 nM for the human enzyme)[1].
Indigo is a deep and rich color dye for indole stain, isolated from the plant Indigofera tinctoria and related species[1].
Maslimomab is a murine monoclonal antibody targeting T-cell receptor. Maslimomab is an immunosuppressive agent[1].
ABT-107 is a potent and selective α7 nAChR agonist with Ki of 0.2-0.6 nM for rat or human cortex α7 nAChRs; displays >100-fold selective versus non-α7 nAChRs and other receptors; potently evokes human and rat α7 nAChR current responses in oocytes (EC50=50-90 nM) enhanced by A-867744; reduces spinal tau hyperphosphorylation in tau/amyloid precursor protein transgenic AD mice; improves cognition in monkey. Alzheimer Disease Phase 2 Discontinued
Benzomalvin B is the less active analogs of Benzomalvin A. Benzomalvin B is weakly active against substance P[1].