ARN14988

Modify Date: 2025-11-29 16:32:35

ARN14988 Structure
ARN14988 structure
Common Name ARN14988
CAS Number 1502027-70-4 Molecular Weight 373.832
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C16H24ClN3O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ARN14988


ARN14988 is a potent inhibitor of acid ceramidase (ACDase) (IC50=12.8 nM for the human enzyme)[1].

 Names

Name ARN14988
Synonym More Synonyms

 ARN14988 Biological Activity

Description ARN14988 is a potent inhibitor of acid ceramidase (ACDase) (IC50=12.8 nM for the human enzyme)[1].
Related Catalog
References

[1]. Realini N, et al. Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION. J Biol Chem. 2016 Jan 29;291(5):2422-34. 

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Molecular Formula C16H24ClN3O5
Molecular Weight 373.832
Exact Mass 373.140442
LogP 2.38
Index of Refraction 1.542
InChIKey PBVLSEVDIRSYGE-UHFFFAOYSA-N
SMILES CCCCCCNC(=O)n1cc(Cl)c(=O)n(C(=O)OCC(C)C)c1=O

 Synonyms

ARN14988
1(2H)-Pyrimidinecarboxylic acid, 5-chloro-3-[(hexylamino)carbonyl]-3,6-dihydro-2,6-dioxo-, 2-methylpropyl ester
Isobutyl 5-chloro-3-(hexylcarbamoyl)-2,6-dioxo-3,6-dihydro-1(2H)-pyrimidinecarboxylate
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