ARN14988

Names

[ CAS No. ]:
1502027-70-4

[ Name ]:
ARN14988

[Synonym ]:
ARN14988
1(2H)-Pyrimidinecarboxylic acid, 5-chloro-3-[(hexylamino)carbonyl]-3,6-dihydro-2,6-dioxo-, 2-methylpropyl ester
Isobutyl 5-chloro-3-(hexylcarbamoyl)-2,6-dioxo-3,6-dihydro-1(2H)-pyrimidinecarboxylate

Biological Activity

[Description]:

ARN14988 is a potent inhibitor of acid ceramidase (ACDase) (IC50=12.8 nM for the human enzyme)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Realini N, et al. Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION. J Biol Chem. 2016 Jan 29;291(5):2422-34.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₁₆H₂₄ClN₃O₅

[ Molecular Weight ]:
373.832

[ Exact Mass ]:
373.140442

[ LogP ]:
2.38

[ Index of Refraction ]:
1.542

Related Compounds

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