Nav1.8-IN-2

Modify Date: 2025-08-25 09:58:58

Nav1.8-IN-2 Structure
Nav1.8-IN-2 structure
Common Name Nav1.8-IN-2
CAS Number 2756250-30-1 Molecular Weight 433.21
Density N/A Boiling Point N/A
Molecular Formula C18H13Cl2F3N2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Nav1.8-IN-2


Nav1.8-IN-2 (compound 35A) is a potent Nav1.8 inhibitor with an IC50 value of 0.4 nM. Nav1.8-IN-2 can be used for researching pain disorders, cough disorders, and acute and chronic itch disorders[1].

 Names

Name Nav1.8-IN-2

 Nav1.8-IN-2 Biological Activity

Description Nav1.8-IN-2 (compound 35A) is a potent Nav1.8 inhibitor with an IC50 value of 0.4 nM. Nav1.8-IN-2 can be used for researching pain disorders, cough disorders, and acute and chronic itch disorders[1].
Related Catalog
Target

Nav1.8:0.4 nM (IC50)

References

[1]. Sabnis RW. 2-Oxooxazolidine-5-carboxamides as Nav1.8 Inhibitors for Treating Pain Disorders, Cough Disorders, and Acute and Chronic Itch Disorders. ACS Med Chem Lett. 2022;13(3):334-335. Published 2022 Mar 1.

 Chemical & Physical Properties

Molecular Formula C18H13Cl2F3N2O3
Molecular Weight 433.21
InChIKey AHMFIVOVWPKBNX-GJZGRUSLSA-N
SMILES O=C1NCC(C(=O)NC(c2ccc(Cl)cc2)c2ccc(Cl)c(C(F)(F)F)c2)O1
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